ABL tyrosine kinases promote colonization and outgrowth of metastatic breast cancer cells by activating not only transcriptional, but also translational programs. Human epidermal growth factor receptor 2-positive (HER2/ERBB2) breast cancer patients often present with brain metastasis. HER2-targeted therapies have not been successful to treat brain metastases in part due to poor blood-brain barrier (BBB) penetrance […]
Author: Nancy McNamara
ABL kinase-mediated regulation of lung epithelial injury and regeneration identifies new therapeutic strategies to treat pathogen-induced lung injury.
Damage to the lung epithelium by respiratory infections is associated with respiratory failure and may result in the induction of acute respiratory distress syndrome which has an incidence of about 200,000 cases in the United States each year and a mortality rate of 25-40%. We found that loss of Abl1 specifically in CC10 (also known […]
ABL-TAZ-AXL signaling axis regulates lung cancer metastasis to brain
Lung cancer is the leading cause of cancer mortality in the U.S., with an overall five-year survival rate of ~16%. Notably, lung cancer patients exhibit the highest prevalence of brain metastasis (40-60 %) among all cancer types. Brain metastases often result in functional impairment, cranial neuropathies, and increased mortality. Currently, there are no effective therapies […]
