OneDukeGen Study




About the study

There is still a lot that we don’t understand about the connections between DNA and health. We already know that certain differences in our DNA can affect our health. For example, some can increase our risk for a few specific health conditions like certain cancers or heart disease. The more we study our DNA, the more we will learn what gene variants mean about us.

The purpose of the OneDukeGen Genomic Sequencing Study and Biorepository (OneDukeGen) is to collect biological samples, and use the samples to analyze DNA, and other material (like RNA) for use in research related to a variety of diseases and conditions.  We are hoping that at least 100,000 people will join. The more people who join, the better chance we have of finding new gene variants and understanding what the ones we already know about mean to our health.

Study Recruitment

The OneDukeGen study is taking place at Duke Health locations in Durham, NC. Study team members are stationed in these locations to collect blood samples from Duke patients during regularly scheduled appointments. Study team members will move to new clinics throughout the six-year life of the study.

Eligible Duke patients will receive an invitation to join the study through their Duke MyChart portal. Some patients will receive an invitation now, while others may not receive an invitation for several years, if at all. Eligibility is dependent on whether the patient has an appointment in a clinic where staff are located. Patients who want to participate in OneDukeGen must keep their upcoming clinic appointment. If the appointment is missed, we may not have another opportunity to collect the blood sample we need.

Some Duke patients will receive an invitation in their Duke MyChart portal for participation via a saliva collection kit that will be mailed to their home. These invitations are part of special research projects within OneDukeGen that only require a DNA sample, and do not need the other elements and information that can be obtained from a blood sample.

See For Participants for active study locations


The Team

OneDukeGen is housed in the Center for Precision Health within the Duke Clinical & Translational Science Institute (CTSI), and operations are managed by CTSI Staff. OneDukeGen is part of the overarching Duke-nference scientific collaboration, with direction on sequencing priorities provided by the joint Genomics Working Group. Therapeutic working groups, composed of Duke researchers and clinicians, bring forward scientific priorities in their respective disease areas to the Genomics Working Group.

Svati Shah

Svati Shah, MD

Principal Investigator
Director, Duke Kannapolis Research

Dr. Svati H. Shah is a physician scientist and Associate Dean of Genomics and Director of Precision Genomics Collaboratory in the Duke School of Medicine; Vice-Chief of Translational Research and Director of the Adult Cardiovascular Genetics Clinic in the Division of Cardiology, Department of Medicine; Co-Director of Translational Research in the Duke Molecular Physiology Institute (DMPI); Director of Duke Kannapolis Research; and a faculty member in the Duke Clinical Research Institute (DCRI). Dr. Shah is Principal Investigator of the MURDOCK Study Community Registry and Biorepository and the Duke principal investigator for the Project Baseline Health Study.

Her research focus is on metabolic and genetic pathways of cardiometabolic diseases, integrating diverse genomic, metabolomic and proteomic techniques for identification of novel mechanisms of disease and biomarkers. Her multi-disciplinary molecular epidemiology lab within the DMPI has quantitative and molecular components and leverages large biorepositories on to perform discovery studies using omics technologies, with subsequent functional validation for mechanistic insight.

Clinical Study Team

Jevon Chavis

Jevon Chavis

Clinical Research Coordinator, Duke Kannapolis

Mr. Chavis joined Duke CTSI to work on the Project Baseline Health Study in Durham, N.C. Prior to joining CTSI, he worked at the Duke Eye Center for 22 years. As a Certified Ophthalmic Assistant (COA), he held several positions throughout his time at the Eye Center which included Visual Fields Technician, Lead Glaucoma Clinic Technician, Lead Ophthalmic Ultrasound Biometrist, and Surgical Coordinator. He holds a bachelor’s degree in Sociology from UNC-Chapel Hill.

Arlene David

Clinical Research Coordinator

As a clinical research coordinator, Arlene David works with the OneDukeGen team. David enrolls study participants for the OneDukeGen study, as well as collects and processes blood samples from research participants. She has been with Duke since 2014, having previously worked at the Duke Regional Hospital Laboratory and the MC3- Carolinas Cord Blood Bank.

Cheryl Robinson

Cheryl Robinson

Clinical Research Specialist, Duke Kannapolis

Cheryl Robinson joined Duke CTSI as a Research Aide and is now a Clinical Research Specialist with the Duke Kannapolis group in Durham, N.C. She spent just over five years serving in the U.S. Navy boot camp in Orlando, Fla. and the Naval Operations Base in Norfolk, Va. to begin courses in underwater sound surveillance. Her advanced training took her to Eureka, Calif. and her career as an Ocean Systems Technician officially began at the base in Dam Neck, Va. Two years later, she was sent to Guam where she continued to serve and earned her honorable discharge.

Jennifer Wilson

Jennifer Wilson

Clinical Research Coordinator, Duke Kannapolis

Jennifer Wilson is part of the Duke Kannapolis group in Durham. Ms. Wilson joined Duke CTSI from the Duke Center for Autism and Brain Development. She has been at Duke for more than 20 years doing clinical research and has worked in the Heart Center, DOCR, and the Duke Department of Psychiatry and Behavioral Sciences. She works on the Project Baseline Health Study.


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