Klaire Bradley

Klaire earned her B.S. in ACS-Certified Chemistry from Johns Hopkins University (2025) where she worked with Dr. John Toscano on the design and synthesis of enzyme-triggered hydropersulfide (RSSH) prodrugs. Outside of the lab, Klaire enjoys playing volleyball, gardening, and spending time with her cat, Farrah.

 

Gu, J.; Liu, Q.; Rodriguez, D.; Lamar, J.; Bradley, K. R.; Keceli, G.; Thampoe, A.; Xiao, Y.; Paolocci, N.; Khodade, V. S.; Toscano, J. P. Esterase-Responsive Mitochondria-Targeted Hydropersulfide Donors Mitigate Doxorubicin Cardiotoxicity While Preserving Anticancer Activity. Angew. Chem. Int. Ed. 2026, 65(5), e21645. DOI: 10.1002/anie.202521645

 

Thampoe, A.; Peng, Y. J.; Yoo, M. S.; Bradley, K. R.; Khodade, V. S.; Rokita, S. E.; Toscano, J. P. Development of Azoreductase-Activated Precursors for Efficient Hydropersulfide Release via 1,6-Elimination. ACS Chem. Biol. 2025, 20(11), 2768–2778. DOI: 10.1021/acschembio.5c00699