Patents
The Becker Group is actively pursuing technology transfer efforts in conjunction with the Duke Office of Technology and Commercialization (Duke OTC). For details on these efforts please contact Dr. Becker (matthew.l.becker@duke.edu) or Dr. Nadine Wong (nadine.wong@duke.edu) at Duke OTC.
Issued US Patents – Most applications include issued foreign patents and patent filings.
1) U.S. Patent 8,354,093 – Cell Permeable Nanoconjugates of Shell-Crosslinked Knedel (SCK) and Peptide Nucleic Acids (PNA’s) with Uniquely Expressed or Over-Expressed mRNA Targeting Sequences for Early Diagnosis and Therapy of Cancer. Inventors: ML Becker, H Fang, X Li, D Pan, R Rossin, X Sun, JS Taylor, JL Turner, MJ Welch, KL Wooley
2) U.S. Patent 9,587,070 – Polymeric structures containing strained cycloalkyne functionality for post-fabrication Azide Alkyne Cycloaddition. Inventors: ML Becker, J Zheng
3) U.S. Patent 9,745,414 – Hyperbranched Amino Acid-Based Poly(ester urea)s for Regenerative Medicine and Drug Delivery. Inventors: ML Becker, J Yu
4) U.S. Patent 9,758,671 – Strain Promoted Crosslinking of PEG-based Hydrogels via Copper Free Cycloaddition. Inventors: ML Becker, RA Weiss
5) U.S. Patent 9,988,492 – Methods for Post-Fabrication Functionalization of Poly(ester urea)s. Inventors: ML Becker, F Lin
6) U.S. Patent 10,537,660 – Resorbable, Amino Acid-Based Poly(ester urea)s Scaffold for Vascular Graft Tissue Engineering. Inventors: ML Becker, Y Gao, DH Reneker
7) U.S. Patent 10,206,781 – Modular Device for Preventing Compression and Instability in a Segmental Defect Repair Scaffold. Inventors: ML Becker, A Isayev, BK Weiner, E Tasciotti
8) U.S. Patent 10,227,440 – Softening Thermoplastic Polyurethanes Using Ionomer Technology. Inventors: ML Becker, RA Weiss, ZK Zander, D Wardius, KW Haider, BD Lowrey
9) U.S. Patent 11,041,039 – Softening Thermoplastic Polyurethanes Using Ionomer Technology. Inventors: ML Becker, RA Weiss, ZK Zander, D Wardius, KW Haider, BD Lowrey
10) U.S. Patent 11,225,543 – Softening Thermoplastic Polyurethanes Using Ionomer Technology. Inventors: ML Becker, RA Weiss, ZK Zander, D Wardius, KW Haider, BD Lowrey
11) U.S. Patent 10,280,261 – Radiopaque, Iodine Functionalized Phenylalanine-Based Poly(Ester Urea)s. Inventors: ML Becker, S Li
12) U.S. Patent 10,414,864 – Degradable amino acid-based poly(ester urea) copolymer adhesives for medical applications. Inventors:ML Becker, J Zhou, A Defante, A Dhinojwala
13) U.S. Patent 10,465,044 – Scalable Method for the Synthesis and Functionalization of Well-Defined Degradable Poly(propylene fumarate). Inventors: ML Becker, D Dean, Y Luo
14) U.S. Patent 10,765,748 – Methods and Molecules for Tethering Bioactive Peptides to Metal Oxide Surfaces. Inventors: ML Becker, W Tang
15) U.S. Patent 10,968,303– Biomimetic Synthetic Rubber and Methods for Controlling Physical Properties through Backbone Double Bond Stereochemistry by Monomer Selection and End Group Modification. Inventors: ML Becker, AP Dove, C, Bell, VX Truong, IA Barker, J Yu
16) U.S. Patent 11,103,613 – Phosphorylated Poly(ester-urea) Based Biomimetic Degradable Tissue. Inventors: ML Becker, V Bhagat
17) U.S. Patent 11,155,668 – Contact Killing QAC Functionalized Thermoplastic Polyurethane for Catheter Applications. Inventors: ZK Zander, ML Becker, A Chiari, S Chambers, W McRoy
18) U.S. Patent 11,499,008 Copolymerization of Propylene Oxide and Maleic Anhydride Using Magnesium Catalysts with Functional Initiators. Inventors: ML Becker, JA Wilson, Y Chen
19) U.S. Patent 11,661,477 Star shaped Poly(propylene fumarate) Copolymers for 3D Printing Applications. Inventors: G Le Fer, ML Becker
20) U.S. Patent 11,771,543 Amino Acid-based Poly(ester urea) Polymer Mesh for Hernia and other Soft Tissue Applications. Inventors: ML Becker, N Dreger, T Parsons, M Hiles
22) U.S. Patent 11,931,478 Post Printing Functionalization of Poly(propylene Fumarate) Scaffolds with Biologics. Inventors: ML Becker, Y Xu
23) U.S. Patent 11,987,668 Synthesis of poly(propylene maleate-co-succinate) by the time-dependent reduction of poly(propylene maleate) double bonds mediated by zinc and acetic acid. Inventors: G Bass, ML Becker
24) U.S. Patent 12,157,795 Improved Synthesis of MG(BHT)2(THF)2. Inventors: ML Becker, A Kleinfehn, SR Peterson
25) U.S. Patent 12,187,844 Block Copolymers of Lactones and Poly(propylene fumarate). Inventors: JA Wilson, S Peterson, ML Becker
26) U.S. Patent 12,258,443 Poly(propylene fumarate)-based copolymers for 3D printing applications. Inventors: ML Becker, YJ Shin, GE Le Fer
27) U.S. Patent NOA Synthesis and Characterization of Well-defined Poly(propylene fumarate) and Poly(ethylene glycol) Block Copolymers. Inventors: ML Becker, RA Dilla, JA Wilson
28) U.S. Patent NOA – Poly(propylene fumarate) Copolymers for Reduced Viscosity Printing. Inventors: ML Becker, Y Shin
Patent Applications Pending
1) Poly(ester urea)s for Shape Memory and Drug Delivery. Inventors: ML Becker, GI Peterson, A Abel
2) US17/209,921 – Antibiotic Eluting Poly(Ester Urea) Films for Infection Control of Implantable Medical Devices. Inventors: ML Becker, A. Alfaro, S Nikam
3) PCT/US2021/029353 – Resorbable Complex Shape Memory Poly(Propylene Fumarate) Star Scaffolds for 4D Printing Applications. Inventors: G Le Fer, ML Becker
4) US 16/765,995 – Amino Acid-based Poly(ester urea) Polymer Mesh for Hernia and Other Soft Tissue Applications. Inventors: ML Becker, N Dreger, T Parsons, C Sonnenberg, M Hiles
5) US17/260,043 – Poly(propylene fumarate) Copolymers for Reduced Viscosity Printing. Inventors: ML Becker, Y Shin
6) 63/067,957 – Bioresorbable, Stereochemically defined elastomers and methods for making and using same. Inventors: ML Becker, YH Hsu, S Nikam
7) 63/113,422 – Tough, Reprocessable Elastomers Derived from Isohexide Monomer Stereochemistry and Hydrogen Bonding. Inventors: ML Becker, AP Dove, J Worsch
8) 63/155,035 – Synthesis and 3D Printing of Triblock Copolymers Through Alternating Ring Opening Copolymerization of Epoxides with Saturated and Unsaturated Cyclic Anhydrides. Inventors: ML Becker, Y Shin
9) 63/272,843 – Degradable, Printable Poly(propylene fumarate)-based ABA Triblock Elastomers and Methods of Making and Using Same. Inventors: ML Becker, S Petersen
10) 63/191,018 – Biostable Polymer Brushes with defined viscosity and optical properties. Inventors: ML Becker, L Clamen, M Karayilan
11) 63/344,186 – Photopolymerized Bottlebrush Hydrogels for All in One Intraoccular Lenses. Inventors: ML Becker, L Clamen, M Karayilan
12) 63/346,432 – Mechanochromism and Strain induced Crystallization in Thiolyne-derived Stereoelastomers. Inventors: ML Becker, VC Ritter, SL Craig
13) 63/445,748 – Resorbable, 3D Printed Composite Plates for Rib Fracture Repair. Inventors: ML Becker, E Augustine, JS Fernandez-Moure
14) 18/182,146. Development of an anti-adhesive bioresorbable elastomer. Inventors: ML Becker, H Levinson
15) 63/492,427 – Resorbable Polymer Vascular Sheaths. Inventors: ML Becker, T Klein & other non-Duke inventors
16) Controlled Delivery of Bupivacaine for Localized Pain Delivery. Inventors: ML Becker, N Brigham-Stinson, RR Ji
17) 63/500,718 – Fluorinated Copolymer Bottlebrushes for Optical Applications. Inventors: ML Becker, V Ritter
18) A drug eluting polymer that can attach to total hip implant and is absorbable. Inventors: ML Becker, T Seyler
19) 63/544,353 – Solvent Free Resorbable Resin for 3D Printing. Inventors: ML Becker, M Segal
20) 63/534,752 – Silyl ether-based Thiol Crosslinkers for Additive Manufacturing. Inventors: ML Becker, E Augustine
21) 63/693,560 – Acceleration of Drug Release from Poly(ester urea)s Using Additives. Inventors: ML Becker, CS Dziewior, RR Ji, L Li
