Research Articles

16. “Catalytic Enantio- and Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers”

Xinxin Shao and Steven J. Malcolmson

Xinxin Shao

Postdoctoral Scientist

15. “Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design”

Nathan J. Adamson, Haleh Jeddi and Steven J. Malcolmson

Nathan Adamson

Graduate Student

14. “Brønsted Acid and Pd–PHOX Dual-Catalysed Enantioselective Addition of Activated C-Pronucleophiles to Internal Dienes”

Sangjune Park, Nathan J. Adamson and Steven J. Malcolmson

Sangjune Park

Postdoctoral Scientist

Nathan Adamson

Graduate Student

13. “Palladium-Catalyzed Synthesis of α-Trifluoromethyl Benzylic Amines via Fluoroarylation of gem-Difluoro-2-azadienes Enabled by Phosphine-Catalyzed Formation of an Azaallyl–Silver Intermediate”

Paige E. Daniel*, Chibueze I. Onyeagusi*, Anthony A. Ribeiro, Kangnan Li and Steven J. Malcolmson

*These authors contributed equally to this work.

Paige Daniel

Graduate Student

Chibueze Onyeagusi

Graduate Student

Kangnan Li

Graduate Student

12. “Development and Mechanistic Investigations of Enantioselective Pd-Catalyzed Intermolecular Hydroaminations of Internal Dienes”

 

Sangjune Park and Steven J. Malcolmson

Sangjune Park

Postdoctoral Scientist

11. “Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines”

Xinxin Shao, Kangnan Li and Steven J. Malcolmson
Highlighted in Synfacts and featured in Organic Chemistry Highlights.

Xinxin Shao

Postdoctoral Scientist

Kangnan Li

Graduate Student

10. “Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles”

 

Nathan J. Adamson, Katie C. E. Wilbur and Steven J. Malcolmson

Nathan Adamson

Graduate Student

Katie Wilbur

Undergraduate Student

9. “2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones”

 

Kangnan Li*, Xinxin Shao*, Luke Tseng, and Steven J. Malcolmson

*These authors contributed equally to this work.

Highlighted in Synform, Synfacts and featured in Organic Chemistry Highlights.

Kangnan Li

Graduate Student

Xinxin Shao

Postdoctoral Scientist

Luke Tseng

Undergraduate Student

8. “Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines”

 

Kangnan Li*, Alexandria E. Weber*, Luke Tseng, and Steven J. Malcolmson

*These authors contributed equally to this work.

Kangnan Li

Graduate Student

Allie Weber

Graduate Student

Luke Tseng

Undergraduate Student

7. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization”

 

Kun Shen,* Angus W. J. Logan,* Johannes F. P. Colell,* Junu Bae, Gerardo X. Ortiz, Jr., Thomas Theis, Warren S. Warren, Steven J. Malcolmson, and Qiu Wang

*These authors contributed equally to this work.

Very Important Paper featured on the journal cover here

Gus Logan

Postdoctoral Scientist

6. “Umpolung Synthesis of 1,3-Amino Alcohols: Stereoselective Addition of 2-Azaallyl Anions to Epoxides”

Paige E. Daniel, Alexandria E. Weber, Steven J. Malcolmson

Org. Lett., 2017, 19, 3490−3493.

Paige Daniel

Graduate Student

Allie Weber

Graduate Student

 

5. “Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange”

Johannes F. P. Colell, Meike Emondts, Angus W. J. Logan, Kun Shen, Junu Bae, Roman V. Shchepin, Gerardo X. OrtizJr., Peter Spannring, Qiu Wang, Steven J. Malcolmson, Eduard Y. Chekmenev, Martin C. Feiters, Floris P. J. T. Rutjes, Bernhard Blümich, Thomas Theis, and Warren S. Warren

Gus Logan

Postdoctoral Scientist

4. “Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd–PHOX Catalyst”

Nathan J. Adamson, Ethan Hull and Steven J. Malcolmson

Nathan Adamson

Graduate Student

Ethan Hull

Graduate Student

3. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange”

Johannes F. P. Colell, Angus W. J. Logan, Zijian Zhou, Roman V. Shchepin, Danila A. Barskiy, Gerardo X. Ortiz Jr., Qiu Wang, Steven J. Malcolmson, Eduard Y. Chekmenev, Warren S. Warren, Thomas Theis

Gus Logan

Postdoctoral Scientist

2. “Hyperpolarization of Nitrogen–15 Schiff Bases by Reversible Exchange Catalysis with para–Hydrogen”

Angus W. J. Logan, Thomas Theis, Johannes F. P. Colell, Warren S. Warren, Steven J. Malcolmson.

Gus Logan

Postdoctoral Scientist

1. “Direct and Cost-Efficient Hyperpolarization of Long-lived Nuclear Spin States on Universal 15N2-Diazirine Molecular Tags”

Thomas Theis, Gerardo X. Ortiz, Angus W.J. Logan, Kevin E. Claytor, Yesu Feng, William P. Huhn, Volker Blum, Steven J. Malcolmson, Eduard Y. Chekmenev, Qiu Wang, Warren S. Warren.

Gus Logan

Postdoctoral Scientist


Work Prior to Duke

Postdoctoral

3. “The Posttranslational Modification Cascade to the Thiopeptide Berninamycin Generates Linear Forms and Altered Macrocyclic Scaffolds”

Steven J. Malcolmson, Travis S. Young, J. Graham Ruby, Peter Skewes-Cox, Christopher T. Walsh

2. “Dihydrophenylalanine: a Prephenate-Derived Photorhabdus luminescens Antibiotic and Intermediate in Dihydrostilbene Biosynthesis”

Jason M. Crawford, Sarah A. Mahlstedt, Steven J. Malcolmson, Jon Clardy, Christopher T. Walsh.

1. “Nine Enzymes are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics”

Wenjun Zhang, Ioanna Ntai, Megan L. Bolla, Steven J. Malcolmson, Daniel Kahne, Neil L. Kelleher, Christopher T. Walsh.


Graduate

6. “Bipyridine Adducts of Molybdenum Imido Alkylidene and Imido Alkylidyne Complexes”

Alejandro G. Lichtscheidl, Victor W. L. Ng, Peter Müller, Michael K. Takase, Richard R. Schrock, Steven J. Malcolmson, Simon J. Meek, Bo Li, Elizabeth T. Kiesewetter, Amir H. Hoveyda.

5. “The Significance of Degenerate Processes to Enantioselective Olefin Metathesis Reactions Promoted by Stereogenic-at-Mo Complexes”

 

Simon J. Meek, Steven J. Malcolmson, Bo Li, Richard R. Schrock, Amir H. Hoveyda.

4. “Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine. Catalyst Development Inspired by Natural Product Synthesis“

Elizabeth S. Sattely, Simon J. Meek, Steven J. Malcolmson, Richard R. Schrock, Amir H. Hoveyda.

3. “Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine Oxides by Mo-Catalyzed Asymmetric Ring-Closing Metathesis”

James Stephen Harvey, Steven J. Malcolmson, Katherine S. Dunne, Simon J. Meek, Amber L. Thompson, Richard R. Schrock, Amir H. Hoveyda, Véronique Gouverneur.

2. “Highly Efficient Molybdenum-Based Catalysts for Enantioselective Alkene Metathesis”

Steven J. Malcolmson*, Simon J. Meek*, Elizabeth S. Sattely, Richard R. Schrock, Amir H. Hoveyda.
*These authors contributed equally

1. “Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centers Through Catalytic Asymmetric Ring-Closing Metathesis”

Ai-Lan Lee, Steven J. Malcolmson, Alessandra Puglisi, Richard R. Schrock, Amir H. Hoveyda.

Reviews and Book Chapters

8. “2-Azadienes as Enamine Umpolung Synthons for the Preparation of Chiral Amines”

Steven J. Malcolmson, Kangnan Li and Xinxin Shao.

Kangnan Li

Graduate Student

Xinxin Shao

Postdoctoral Scientist

7. “Dimethoxymethylsilane”

Xinxin Shao and Steven J. Malcolmson.
(Encyclopedia of Reagents for Organic Synthesis, Second Edition; Paquette, Bode, Charette, Rovis, Eds.; DOI: 10.1002/047084289X.rn02262); Wiley-VCH: Weinheim, 2019.

6. “Catalyst-Controlled Stereoselective Olefin Metathesis”

Amir H. Hoveyda, R. Kashif M. Khan, Sebastian Torker, Steven J. Malcolmson.
(Handbook of Olefin Metathesis, Vol. 2, Second Edition, Grubbs, Wenzel, O’Leary, Khosravi, Eds.; 503–562); Wiley-VCH: Weinheim, 2015.

5. “Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks”

Christopher T. Walsh, Steven J. Malcolmson, Travis S. Young.

4. “Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis”

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek, Adil R. Zhugralin.
(Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts; Cossy, Arseniyadis, Meyer, Eds.; 343–348); Wiley-VCH: Weinheim, 2010.

3. “Catalytic Enantioselective Olefin Metathesis in Natural Product Synthesis. Chiral Metal-Based Complexes that Deliver High Enantioselectivity and More“

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek, Adil R. Zhugralin.

2. “Catalytic Enantioselective Olefin Metathesis Reactions”

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek, Adil R. Zhugralin.
(Catalytic Asymmetric Synthesis, Third Edition; Ojima, Ed.; 739–770); Wiley-VCH: Weinheim, 2010.

1. “Molybdenum,[(S)-3,3′-bis(1,1-dimethylethyl)-5,5′,6,6′-tetramethyl[1,1′-biphenyl]-2,2′-diolato(2-)-kO,kO’]-2-methyl-2-phenylpropylidene)-[tricyclo1decan-1-aminato(2-)]”

Steven J. Malcolmson, Amir H. Hoveyda, Richard R. Schrock.
(Encyclopedia of Reagents for Organic Synthesis, Second Edition; Paquette, Crich, Fuchs, Molander, Eds.; 1765–1768); Wiley-VCH: Weinheim, 2009.


Patents

2. “Complexes for Use in Metathesis Reactions”

Amir, H. Hoveyda, Richard R. Schrock, Simon, J. Meek, Steven, J. Malcolmson, Elizabeth T. Kiesewetter
US Patent No. 20120302710 A1; Publication Date: November 29, 2012.

1. “Catalysts for Metathesis Reactions Including Enantioselective Olefin Metathesis, and Related Methods”

Steven J. Malcolmson, Amir H. Hoveyda, Simon J. Meek, Richard R. Schrock.
US Patent No. 9687834; Issue Date: June 27, 2017.