The overall goal of our research is to identify and characterize the key mechanisms of skin innate immunity, with specific focus on host-microbial interactions, immune surveillance and repair functions. Understanding the complex molecular and cellular immune dysregulation in non-healing wounds, skin infection, cancer and allergic and inflammatory skin diseases poses great challenges in today’s medicine. We use interdisciplinary approaches, combining various disease mouse models, human skin tissues and cells, and techniques from immunology, cell biology and pharmacology to ultimately reveal strategies that coordinate, regulate or co-opt innate immunity in the skin. Identifying such mechanisms will help in the development of new immune-modulatory therapeutics.
We have two main areas of investigation:
- Understanding how epithelial skin cells and immune cells regulate barrier function, wound repair, and host defense in the skin
- Understanding how skin immune cells drive cutaneous inflammation relevant to inflammatory skin diseases and cancer immunity