January 20, 2022

Cellular factors regulating EBV infection in epithelial cells

Despite extensive studies of the EBV-infected B cell latency reservoir and lymphomagenesis, the EBV-positive cancer affecting the most people is gastric cancer with nearly 10% of these tumors harboring the virus. In addition, EBV is virtually 100% associated with nasopharyngeal carcinoma. In recent years, de novo infection of epithelial cells by EBV has been used to characterize latency establishment and pathogenesis. However, similar to B cell infection, this process is highly inefficient. Given our background in characterizing host restriction factors in the B cell system, we have begun to define those factors preventing EBV latent infection and tumorigenesis in epithelial cells. Check out one of our papers here!




Lab folks that work on this project: Lyla, and Camille