The Kinesin-13 Family

The Kinesin-13 (formerly MCAK/KIF2) family tree was found using the heuristic search method of PAUP v4.0b10 (Swofford, 2002), a maximum parsimony program, and random stepwise addition. The tree is one of two optimal trees that resulted from 600 trees that were built. The bootstrap values adjacent to the nodes are the percentages of 1,810 heuristic bootstrap trials in which the indicated groups were found. The tree contains Kinesin-13 proteins from humans and several model organisms. Kinesin-13 proteins from other organisms are also shown in the table and sequence alignment below. There are three Kinesin-13 proteins in Drosophila, the mouse and humans. Pairwise comparisons of full-length protein and motor domain sequences identify putative orthologues as [DmKlp10A, MmKif2A, HsKin2 (HsKif2)]; [DmKlp59C, MmKif2C, HsMCAK]; and [DmKlp59D, MmKif2B, HsKlp17] (C.D. Yankel & S.A. Endow, 2006). The Kinesin-13 proteins function in MT disassembly in mitosis and interphase.

Species/protein Molecular mass (kDa) Motor polarity & velocity Subcellular localization Comments
C. fusiformis DSK1 63 ND Spindle
P. falciparum L2165w
D. melanogaster Klp10A ND ND
D. melanogaster Klp59D
D. melanogaster Klp59C ND ND
H. sapiens Klp17q22 76
H. sapiens Kin2 77 ND ND
H. sapiens MCAK 81 ND ND
C. elegans K11D9.c 77 ND ND
A. thaliana MGL6.9 89
A. thaliana MSL1.9 77
L. major Kin 74 ND ND
C. griseus MCAK 83 ND Kinetochore Localizes to kinetochore, anchors kinetochore MTs?
M. musculus KIF2 81 Plus, 28 µm/min Membranous vesicles Abundant in developing axons, transport of specific organlles?
M. musculus KIF2C 75 ND ND
R. norvegicus KRP2 ND ND ND
X. laevis KCM1 83 ND ND
X. laevis KIF2 ND ND ND
          1       10        20        30        40        50        60        70        80        90        100       110       120       130       140       150       160       170       180       190       200       210       220       230       240       250       260       270       280       290       300       310       320       330       340                
          '        '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '         '                  
CfDSK1    TNSNICIAVRKRPISDKERQKLDHDSVSCFQNKVWIHSAKLKVDGITKYLTHNSFQLDHTFGEDSTTEQIYLATTLPLVDHVVSTQGRATVFCYGQTGSGKTYTMNG---------IQQILAYDLYGQ-LAEHTDD-----LEITVAFFELYSGNVLDLLHGCQ-RCKLLEDGNGEVNITGLREVPAPTPEAFLQVIEEGHSLRTTQKTEANDASSRSHAICQVFLRDY-GGNLRGKLGLVDLAGSERGSDTKQHNSQRRTESADINTSLLALKECIRALGQKSAHVPYRGSKLTLILKDCF-SPDSKTTMVATVSPGASAADHSLNTLRYADRIKEQRVSSNGQ  CfDSK1 
DmKlp10A  DDHQITVCVRKRPISRKEVNRKEIDVISVPRKDMLIVHEPRSKVD-LTKFLENHKFRFDYAFNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQDCKNGIYAMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLSDKQ-KLRVLEDGKQQVQVVGLTEKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIVLRPQGSTKIHGKFSFIDLAGNERGVDTSSADRQTRMEGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGEKSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIVE  DmKlp10A
DmKlp59C  NCHQIMVCVRKRPLRRKELADREQDVVSIPSKHTLVVHEPRKHVN-LVKFLENHSFRFDYVFDEECSNATVYEFTARPLIKHIFDGGMATCFAYGQTGSGKTYTMGGQFPGRHQSSMDGIYAMAAKDVFSTLKTVPYNKLNLKVYCSFFEIYGTRVFDLLMPGKPQLRVLEDRNQQVQVVGLTQNPVQNTAEVLDLLELGNSVRTSGHTSANSKSSRSHAVFQIVLRSAAGEKLHGKFSLIDLAGNERGADNSSADRQTRLEGSEINKSLLVLKECIRALGRQSSHLPFRGSKLTQVLRDSFIGKKVKTCMIAMISPCLHSVEHTLNTLRYADRVKELSVESIPS  DmKlp59C
HsKin2    DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVD-LTRYLENQTFRFDYAFDDSAPNEMVYRFTAKPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKT-KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRK--GKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVDPTAA  HsKin2
HsMCAK    EEHRICVCVRKRPLNKQELAKKEIDVISIPSKCLLLVHEPKLKVD-LTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKAQNASKGIYAMASRDVFLLKNQPCYRKLGLEVYVTFFEIYNGKLFDLLNKKA-KLRVLEDGKQQVQVVGLQEHLVNSADDVIKMLDMGSACRTSGQTFANSNSSRSHACFQIILRAK--GRMHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIATISPGISSCEYTLNTLRYADRVKELSPHSGPS  HsMCAK
CeK11D9.c NENRISVCVRKRPLNKKELTKAEVDVITIPSRDITILHQPQTRVD-LTKYLDNQKFRFDYSFDEYANNELVYRFTAAPLVKTVFDNGTATCFAYGQTGSGKTHTMGGDFSGKKQNASMGIYALTARDVFRMLEQPQYRRKDLSVHCAFFEIYGTKTYDLLNDKA-ELRVLEDKMQKVQVVGLKEEQAHNEQDVLELINKGTLVRTAGTTSANANSSRSHAIFQIILRQG--KKVWGKFSLIDLAGNERGQDTRECDRDTRKEGANINTSLLALKECIRGMARNSSHVPFRQSKLTMVLRDSFIGEKSRTVMISMISPGISSSDHTLNTLRYADRVKEMGTDGSGE  CeK11D9.c 
LmKin     RKSRILVAIRKRPLSAGEQTNGFTDIMDADNSGEIVLKEPKVKVD-LRKYTHVHRFFFDEVFDEACDNVDVYNRAARALIDTVFDGGCATCFAYGQTGSGKTHTMLGKGPEP------GLYALAAKDMFDRLTSD------TRIVVSFYEIYSGKLFDLLNGRR-PLRALEDDKGRVNIRGLTEHCSTSVEDLMTIIDQGSGVRSCGSTGANDTSSRSHAILEIKLKAKRTSKQSGKFTFIDLAGSERGADTVDCARQTRLEGAEINKSLLALKECIRFLDQNRKHVPFRGSKLTEVLRDSFIG-NCRTVMIGAVSPSNNNAEHTLNTLRYADRVKELKRNATER  LmKin
CgMCAK    EEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLFVHEPKLKVD-LTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNTSKGIYAMASRDVFLLKSQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKA-KLRVLEDSKQQVQVVGLQEYLVNCADDVIKMLNMGSACRTSGQTFANSNSSRSHACFQILLRAK--GRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKECIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGLS  CgMCAK
MmKIF2    DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVD-LTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKT-KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRK--GKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLRLKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKEFGISPSDI  MmKIF2
MmKIF2C   DEHRICVCVRKRPLNKKETQMKDLDVITIPSKDVVMVHEPKQKVD-LTRYLENQTFRFDYAFDDSAPNEMVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFLMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKT-KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIDIGNSCRTSGQTSANAHSSRSHAVFQIILRRK--GKLHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELTVNPAAA  MmKIF2C
RnKRP2    EEHRICVCVRKRPLNKQELAKKEIDVISVPSKCLLLVHEPKLKVD-LTKYLENQAFCFDFAFDETASNEVVYRFTARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGDLSGKSQNASKGIYAMASRDVFLLKNQPRYRSLNLEVYVTFFEIYNGKVFELLNKKA-KLRVLEDSKQQVQVVGLQEYLVTCADDVIKMINMGSACRTSGQTFANSNSSRSHACFQILLRAK--GRLHGKFSLVDLAGNERGADTSSADRQTRMEGAEINKSLLALKESIRALGQNKAHTPFRESKLTQVLRDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELSPHSGPS  RnKRP2
XlKCM1    EEHRICVCVRKRPLNKQELSKKEIDIISVPSKNIVLVHEPKLKVD-LTKYLENQAFRFDFSFDETATNEVVYRFTARPLVQSIFEGGKATCFAYGQTGSGKTHTMGGDFSGKSQNVSKGVYAFASRDVFLLLDQPRYKHLDLDVFVTFFEIYNGKVFDLLNKKT-KLRVLEDAKQEVQVVGLLEKQVISADDVFKMIEIGSACRTSGQTFANTSSSRSHACLQIILRRG--SKLHGKFSLVDLAGNERGVDTASADRITRMKGAEINRSLLALKECIRALGQNKSHTPFRESKLTQILRDSFIGENSRTCMIAMLSPGFNSCEYTLNTLRYADRVKELSPQNAET  XlKCM1
XlKCM2    DEHRICVCVRKRPLNKKETTIKDLDVITIPIKDVVMVHEPKQKVD-LTRFLENQTFRFDYAFDETAPNETVYRFTARPLVETIFERGMATCFAYGQTGSGKTHTMGGDFSGKNQDCSKGIYALAARDVFQMLKKPNYKKLELQVYATFFEIYSGKVFDLLNRKT-KLRVLEDGKQQVQVVGLQEREVKCVEDVLKLIEIGNSCRTSGQTSANAHSSRSHAVFQIILRKK--GKMHGKFSLIDLAGNERGADTSSADRQTRLEGAEINKSLLALKECIRALGRNKPHTPFRASKLTQVLRDSFIGENSRTCMIATISPGMASCENTLNTLRYANRVKELDPSRCRR  XlKCM2

Go to the MT Disassembly page.

If you use diagrams, trees, or sequence alignments from the Kinesin site, we ask that you cite either the home page and authors, or the appropriate source publication in your work.
Copyright 1996-2005. All rights reserved.

Created 16 July 1996 00:00 GMT
Modified 14 July 2006 2:31 GMT