Advancing epithelial cancer research

Our Research Focus

Using our unique human cell transformation system, we are trying to

  • Understand human cancer initiation, progression and evolution
  • Investigate the pathogenesis of prostate and other epithelial cancers
  • Identify oncogenic drivers for targeted therapy.

Reprogramming normal human cells into cancer cells by recurrent genetic alterations found in human cancers (Science 2018)

Convergence of transcriptional and epigenetic landscapes in two different cancer types (Science 2018 and Cancer Cell 2019)

A novel genetically engineered small cell bladder cancer model reveals potential therapeutic targets (PNAS 2020)

Which cells are origin for human prostate cancer? (PNAS 2016)