Home » Research

Research

I have a strong interest in healthcare innovation and have sought out biomedical research opportunities to build my skills. As a member of the Chilkoti lab at Duke, I developed low-cost, point-of-care diagnostic devices that utilize antibody-based biosensors for rapid detection of protein markers. My specific project was centered on designing a diagnostic test to triage risk of complications and growth failure in children with severe acute malnutrition. This test leveraged a recent study showing that the strongest predictors of mortality in malnourished children were circulating leptin and IL-6 levels, which may provide an alternative to inconsistent anthropometric measurements that are conventionally used. A point-of-care test targeting these markers has the potential to improve care of pediatric malnutrition patients by providing access to reliable clinical evaluation in limited resource settings. Additionally, I led another project that utilized cell microarray techniques to profile functional heterogeneity in tumors and to isolate rare variants that confer drug resistance.

I have conducted this research under the guidance of my GCS mentor, Dr. Ashutosh Chilkoti, through the following independent study courses:

  1. BME 493: Cancer Diagnostics (Spring 2020)
  2. BME 493: Cell Microarray for Drug Resistance (Fall 2018)
  3. EGR 491: Microarray on Polymer Surfaces (Spring 2018)
  4. EGR 393: Clinical Bioanalysis (Fall 2017)
  5. EGR 393: POC Malnutrition Biosensors (Spring 2017)

For more details about my research projects, click on the links to the left.

Cell Microarrays

High-throughput identification of drug resistant cells

Point-of-Care Diagnostics

Development of a cost-effective platform for biomarker screening in limited resource settings

Opti-Diag Project

Clinical validation of diagnostic tools for childhood Severe Acute Malnutrition (SAM)