CIX3 Small Animal and Cell Irradiator
The Xstrahl CIX3 irradiator is designed for preclinical research. It’s a 320kV self-contained cabinet irradiator The Duke Irradiator Core has two units. The unit located in the Sands building may be used for both in vitro and in vivo biological research. It is also suitable for certain material science investigations. The unit located in the GSRB research facility is primarily for in vivo work.
The CIX3 irradiator has been utilized at this and other institutions for many types of in vitro and in vivo radiation studies.
- Low dose radiobiology studies: These studies investigate the biological effects of low doses of radiation.
- Hypoxia research: This research focuses on conditions where the body or a region of the body is deprived of adequate oxygen supply.
- DNA repair mechanisms: The irradiator can be used to study how cells repair DNA damage caused by radiation.
- Combination therapy studies: These studies investigate the effects of using multiple therapeutic approaches together.
- Tumour microenvironment studies: These studies focus on the environment around a tumor, including the surrounding blood vessels, immune cells, fibroblasts, signaling molecules, and the extracellular matrix.
- Radioimmunotherapy studies: These studies involve using radiation to boost the immune system’s response to cancer.
- Bystander effect studies: These studies investigate how cells that haven’t been exposed to radiation can be affected by signals from nearby irradiated cells.
- Immunology studies: These studies focus on the immune system and its response to threats, including how it responds to radiation.
- Normal tissue toxicity studies: These studies investigate the harmful effects of radiation on normal, healthy tissues.
- Bone marrow chimeras studies: These studies involve replacing the bone marrow of an organism with bone marrow from a different organism.
Please contact Core Manager
Ken Young for X-ray training and facility questions
