A year’s worth of updates!

A lot of things happened in lab over the last 18 months!  Here are some of the highlights.


Lee, J, Harris, AN, Holley, CL, Mahadevan, J, Pyles, KD, Lavagnino, Z, Scherrer, DE, Fujiwara, H, Sidhu, R, Zhang, J, Huang, SC-C, Piston, DW, Remedi, MS, Urano, F, Ory, DS, and Schaffer, JE. “Rpl13a small nucleolar RNAs regulate systemic glucose metabolism.” The Journal of clinical investigation 126, no. 12 (December 2016): 4616-4625.

Gokhale, NS, McIntyre, ABR, McFadden, MJ, Roder, AE, Kennedy, EM, Gandara, JA, Hopcraft, SE, Quicke, KM, Vazquez, C, Willer, J, Ilkayeva, OR, Law, BA, Holley, CL, Garcia-Blanco, MA, Evans, MJ, Suthar, MS, Bradrick, SS, Mason, CE, and Horner, SM. “N6-Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection.” Cell host & microbe 20, no. 5 (November 2016): 654-665.

Holley, CL. “The Challenges of Bedside-to-Bench Research in Pediatric Cardiology.” Journal of cardiac failure 23, no. 1 (January 2017): 81-82.

McCommis, KS, Hodges, WT, Brunt, EM, Nalbantoglu, I, McDonald, WG, Holley, C, Fujiwara, H, Schaffer, JE, Colca, JR, and Finck, BN. “Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis.” Hepatology (Baltimore, Md.) 65, no. 5 (May 2017): 1543-1556.

Fry, NJ, Law, BA, Ilkayeva, OR, Holley, CL, and Mansfield, KD. “N6-methyladenosine is required for the hypoxic stabilization of specific mRNAs.” RNA (New York, N.Y.) 23, no. 9 (September 2017): 1444-1455.


New Grants and Awards

NIH R03 (PI: Holley) Role of snoRNAs in regulation of cardiac hypertrophy

NIH R01 (PI: Zennadi) Role of RBC Reactive Oxygen Species and Their Vicious Cycle in Sickle Vasculopathy

NIEHS R41 Sub-Award (PI: Agris) Mass Spectrometric Screening of the Effect of Chemical Toxicants on the Human Epitranscriptome during Stem Cell Differentiation

AHA Strategically Focused Heart Failure Research Network (PI: Felker): Duke Center for the Study of Heart Failure and Diabetes

Duke Heart Center Leadership Council Junior Faculty Development Award: Dr. Holley

Duke Health Fellow Award: Dr. Holley

Duke Strong Start Physician-Scientist Award: Dr. Holley

NIH T32 Fellowship: Dr. Law

Secondary Appointment to Molecular Genetics and Microbiology: Dr. Holley


Posters and Presentations

2017 Gordon Research Conference: RNA Editing. Ventura, CA. (Dr. Law)

2017 Duke-Stanford Cardiovascular Research Symposium (Dr. Ho)

2017 Duke Molecular Genetics and Microbiology Departmental Retreat (Drs. Law and Ho)

2017 North Carolina Symposium on RNA Biology XII (Dr. Law, who was awarded the Illumina Prize for her poster!)


Visiting Professor

Paul Agris, PhD


New lab member!

Lab manager:  Xinhe Yin


Welcome to Dr. Ho!

A belated welcome to Dr. Hsiang-Ting Ho! Hsiang-Ting joined the lab in April as a post-doctoral associate.  She was previously working with Dr. Sandor Györke at The Ohio State University, where her research focused on calcium signaling, reactive oxygen species, and other factors that underlie the beneficial effects of parasympathetic stimulation in human heart failure.

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