Transfusion Medicine and Hemoglobinopathies represent a significant component of the T32 training program. Research in this track involves both basic and clinical research programs. Basic/translational programs in this track encompass biochemistry and genetics of blood cell antigens, (Telen), mechanisms of immune destruction of blood cells by allo-and autoantibodies (Telen, Arepally); transfusion for hemoglobinopathies (Telen, Strouse & Shah); mechanisms of red cell phospholipid exposure (Yang, Telen), oxidative damage (Zennadi), storage and nitric oxide generation (McMahon) focuses on sickle cell disease therapeutics (Telen & Shah); environmental triggers for sickle cell disease (Strouse), aging in sickle cell disease (Telen & Strouse); mobile tools for monitoring sickle cell pain (Shah); malaria chemoprevention in sickle cell cell disease (Taylor) and blood separation technologies (Huang)..
| Track I Faculty: Transfusion Medicine & Hemoglobinopathies | ||
|---|---|---|
| Basic/Translational Research Faculty (Area of Interest) | Clinical Research Faculty (Area of Interest) | |
| Ashley-Koch, Allison PhD (Genomics of Sickle Cell Disease) | Mitch Knisely, MD (Pain Management in Sickle Cell) | |
| Lee, Grace MD (Neutrophil/RBC interactions in sickle cell disease) | Lee, Grace MD (clinical effects of therapeutic apheresis) | |
| McMahon, Timothy MD, PhD (RBC storage/nitric oxide) | Oyedeji, Charity MD (aging & sickle cell) | |
| Telen, Marilyn MD (Sickle RBC biology & alloimmunization) | Rothman, Jennifer MD (pediatric sickle cell care) | |
| White, James PhD (Heterochronic transfusions between young/old) | Shah, Nirmish,MD (Sickle cell/mobile health) | |
| Yang, Huanghe PhD (RBC membrane phospholipid/ion channels) | Shaz, Beth MD (Stem cell collections; novel cellular therapies) | |
| Strouse, JJ MD, PhD (Sickle cell environment & aging) | ||
| Taylor, Steve MD, MHS (Sickle cell & Malaria) | ||
| Telen, Marilyn MD (Sickle cell new therapeutics) | ||
Educational Resources for Track I Trainees
| Conferences and Seminars available to Track I participants | ||
| Conference | Conference Description | Attendees and Interactions |
| Interdisciplinary Hematology Conference | This interdisciplinary conference covers case-based discussions as well as quarterly basic scientific research seminars. Held weekly, Tuesday AM | MDs, PhDs in adult and pediatric hematology, transfusion medicine, pathology and biochemistry. |
| Transfusion Medicine Rounds | Clinical rounding conference held in Transfusion Medicine four times a week for one hour. | Transfusion Medicine Faculty, clinical fellows and residents. |
| Sickle Cell Research Program | This is a monthly seminar to discuss clinical/translational and basic research activities of the Duke Adult and Pediatric Sickle Cell Programs. | MDs, PhDs, research personnel, grad students studying sickle cell disease, other interested investigators |
| Immunology Research Seminars | Invited speaker series to review major research developments in immunology. Held weekly, Tuesday 11 AM | PhDs, MDs, post-doctorate fellows and graduate students |
| Biochemistry Seminars | Invited speaker series of nationally and internationally recognized researchers. Held weekly, Fridays at Noon. | Biochemistry faculty, graduate students and post-doctorate fellows |
Graduate courses available to Track I Trainees
Trainees in Track I are encouraged to pursue additional graduate level classes in biochemistry and immunology to supplement their basic and/or clinical research.
For trainees involved in basic research, suggested coursework include: introductory class Principles of Immunology (IMM244,) Contemporary Topics in Membrane Biology (Biochem 631), Immunology (IMM291), Immunopathogenesis (IMM210), Structural Biochemistry I/II (IMM/BIOCHEM 258/259), Biophysical Methods (BIOCHEM 681) and Molecular Aspects of Disease (PTH385).
For trainees involved in clinical research, in addition to introductory courses in statistics (CRP241& 245) and principles of clinical research (CRP242), they would take Proteomics and Protein Biology in Medicine (CRP 257) and Patient-reported Outcomes in Medicine (CRP 271).
