HARP awarded a new R01 grant from NIDA

This 5-year grant entitled, Modeling the effects of chronic marijuana use on neuroinflammation and HIV-related neuronal injury, was awarded to Dr. Christina Meade (PI) and Dr. Sheri Towe (Co-I) in the HIV and Addictions Research Program at Duke. The hypothesis-drived proposal will investigate the underlying pathophysiological mechanisms of HIV-associated brain dysfunction and the mechanisms through which chronic marijuana use may alter the central nervous system. The cohort of 140 adults will complete cutting-edge neuroimaging, immune and cytokine profiling, and neuropsychological testing three times over 2 years. Capitalizing on ultrahigh-resolution magnetic resonance imaging (MRI) capabilities at Duke, we will use multimodal, multi-parametric sequences to investigate neuroinflammatory and neurodegenerative processes. This multidisciplinary project is a collaborative effort with Dr. Brian Soher in Radiology, Dr. Mehri McKellar in Medicine, and Dr. Doug Williamson in Psychiatry.

Permanent link to this article: https://sites.duke.edu/harp/2020/09/30/1861/

New pub on the potential for PrEP in persons who use stimulant drugs

The HARP team recently published an article titled “Examining the Potential of Pre‑exposure Prophylaxis (PrEP) for HIV Prevention in a Community Sample of Persons Who Use Stimulants Living in the Southern United States” in AIDS and Behavior. Of 352 participants, over half (61%) met criteria for PrEP candidacy, but less than 20% had heard of PrEP. Willingness to take PrEP  was high, and PrEP candidates reported more frequent and problematic stimulant use relative to non-candidates. Our results show that persons who use stimulants are a high-risk population that could benefit significantly from PrEP.  Click here to read more!

Permanent link to this article: https://sites.duke.edu/harp/2020/08/11/read-our-latest-publication-examing-the-potential-for-prep-among-persons-who-use-stimulants-in-aids-and-behavior/

HARP welcomes Rimel Mwamba to the team

Rimel joined the HARP team in August as a Clinical Research Specialist , Senior.  Rimel graduated in May 2018 from the University of North Carolina at Chapel Hill with a dual enrollment at Duke University through the Robertson Scholars Program. She earned a BA in Global Studies with a minor in Chemistry and a Human Development Certificate. After graduation, Rimel worked as a Research Administration Fellow in the Duke University School of Medicine , and then joined the Duke Global Health Institute as an NIH training fellowship focused on implementing an HIV stigma reduction intervention for pregnant and postpartum women in Kilimanjaro, Tanzania. Rimel will work with HARP to gain clinical research experience prior to pursuing medical school.

Permanent link to this article: https://sites.duke.edu/harp/2020/08/06/harp-welcomes-rimel-mwamba-to-the-team/

Web-based cognitive training is a promising intervention for improving working memory

The HARP team recently published a journal article titled “Web‑Based Cognitive Training to Improve Working Memory in Persons with Co‑Occurring HIV Infection and Cocaine Use Disorder: Outcomes from a Randomized Controlled Trial” in AIDS and Behavior. The aim of this paper was to examine the feasibility and effectiveness of a web-based cognitive training intervention to improve working memory in persons living with HIV and cocaine use disorder. Treatment completion  (74%) and retention rates (97%) were high, and the intervention successfully reduced working memory deficits in the experimental arm relative to the control arm.  Click here to read more!

Permanent link to this article: https://sites.duke.edu/harp/2020/08/05/our-latest-research-using-a-web-based-cognitive-intervention-is-published-in-aids-and-behavior/