The Paul M. Gross Hall, at the northeast corner of Science and Towerview, was named for long-time Chemistry Department Chairman Paul Gross. The 146,400-square-foot building opened in 1968.

In 2010, the first floor of the building was revitalized as the Duke Energy Hub - an active, collaborative learning space hosting the Energy Initiative and several undergraduate courses.

Further growth in 2011 included The Duke Center for Sustainability and Commerce and Duke Innovation and Entrepreneurship.

In Spring 2013, Gross Hall space on the 2nd and 3rd floors added the Department of Political Science, the Social Science Research Institute, the Information Initiative at Duke and the Pratt School of Engineering Researchers.

The final project, completed in Fall 2015, was the renovation of the Ground Level, which involved the creation of a new 7,600 square-foot student-focused, project-centered, collaborative space. Students from Pratt and across Duke can build ideas from the ground up in space which includes optics and electronic shops, work benches, light machining capability, a computer room, teaching and meeting spaces and dedicated project space.