Our work on olfactory neuroblastoma is now out; superb collaboration between Goldstein lab and Oliver lab at Duke.

https://www.cell.com/cancer-cell/fulltext/S1535-6108(24)00164-8

 

 

 

 

 

 

 

 

 

 

 

 

 

Schematic overview if the human olfactory mucosa. (A) coronal CT scan depicting location of the olfactory cleft. (B) zoomed image of olfactory cleft region. (C) Schematic of the olfactory neuroepithelium lining the olfactory cleft region, housing the olfactory sensory neurons and related cell populations. (D) Cilia projection from olfactory neurons into the nasal airspace contain olfactory receptors, G-protein couple receptors that are activated by binding of odor ligands.

 

Graphical abstract summarizing model for PRC2 activity in adult olfactory epithelial renewal. Evidence from ChIP-seq, scRNA-seq, conditional Eed deletion and genetic fate mapping support a role for PRC2 in regulating cell fat and reinforcing a neuronal lineage and repressing non-neuronal lineage transcription factors in GBCs. See Ko T et al 2023.

 

Schematic depicting model of long-COVID olfactory dysfunction. See Finlay JB et al, Sci Transl Med. 2022. PMID: 36542694, and also Kim S, et al, World J Otorhinolaryngol Head Neck Surg Feb 2024; DOI: 10.1002/wjo2.165.