Technologies & Methods

Assay Development and Implementation

Statistical Methods and Protocols

  • BIRD:  Majoros WH, Kim YS, Barrera A, Li F, Wang X, Cunningham SJ, Johnson GD, Guo C, Lowe WL, Scholtens DM, Hayes MG, Reddy TE, Allen AS. Bayesian estimation of genetic regulatory effects in high-throughput reporter assays. Bioinformatics. 2020;36(2):331-8. PubMed PMID: 31368479
  • SGRF: Predicting gene structure changes resulting from genetic variants via exon definition features.
    Majoros WH, Holt C, Campbell MS, Ware D, Yandell M, Reddy TE. Bioinformatics. 2018 Nov 1;34(21):3616-3623. doi: 10.1093/bioinformatics/bty324.PMID: 29701825 

Population and Evolution Genetics/Genomics

  • Orion: Detecting regions of the human noncoding genome that are intolerant to variation using population genetics. Gussow AB, Copeland BR, Dhindsa RS, Wang Q, Petrovski S, Majoros WH, Allen AS, Goldstein DB.PLoS One. 2017 Aug 10;12(8):e0181604. doi: 10.1371/journal.pone.0181604. eCollection 2017.PMID: 28797091