Research

CCGR aims working together

To achieve the goals of this project, we will drive synergistic innovation in four key areas:

  1. Experimental techniques to measure the function of combinations of cis-acting regulatory variants at several genomic scales;
  2. Statistical methods and evolutionary principles to model how those interactions influence gene expression and other phenotypes;
  3. Disease applications revealing different ways that combinations of regulatory elements and variants impact the spectrum from common to ultra rare disease; and
  4. The first public resource to disseminate datasets detailing the function of noncoding variants, alone and in combination, to basic scientists and translational scientists alike.

Those innovations together will be a windfall for truly understanding the many roles that gene regulation plays in human biology.