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Sarah

Sarah Angle

4th year, PhD Candidate

Department

Chemistry

@ s.seay@duke.edu

Previous educational background: B.S. Chemistry, B.S. Biochemistry, B.S. Biological Sciences: Biomedical; Virginia Tech

Research Project: My work focuses on combating the antibiotic resistance crisis using prodrugs. I am interested in designing scaffolds which selectively target bacterial resistant enzymes to induce cell death. My project lies at the interface of organic synthesis and chemical biology where I use techniques ranging from column chromatography to cell microdilution assays.

Personal Bio: I’m an avid runner who loves spending time outdoors hiking and exploring with my pups. I also enjoy reading romance and fantasy novels. Family is everything to me, and I’m always up for good food, great company, and making the most of life’s little adventures.

Publications:

Duda, Addison M., Helena R. Ma, César A. Villalobos, Sophia A. Kuhn, Sarah S. Angle, Katherine He, Abigail C. Jackson, et al. “An Engineered Prodrug Selectively Suppresses β-Lactam-Resistant Bacteria in a Mixed Microbial Setting.” ACS Infect Dis 11, no. 7 (July 11, 2025): 1956–67. https://doi.org/10.1021/acsinfecdis.5c00179.