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mackenzie

Mackenzie Smith

4th year, PhD Candidate

Department

Chemistry

@ mackenzie.k.smith@duke.edu

Previous educational background: B.S. Biochemistry, Biology, and Chemical Biology with a minor in Environmental Studies; Brandeis University

Research Project: My research project focuses on the antifungal action of histatin-5. Of particular interest is the effect essential metals have on that antifungal activity. I use cellular assays along with fluorescence microscopy and other chemical biology techniques to unravel the mysteries of histatin-5.

Personal Bio: I am an avid soccer fan and enjoy following the local teams in the area as well as my EPL team. When not watching soccer, I enjoy cooking and baking treats for the lab as well as going on outdoor adventures in the woods and out by the coast!

Publications:

Zhao, H.; Kumar, P.; Sobreira, T. J. P.; Smith, M.; Novick, S.; Johansson, A.; Luchniak, A.; Zhang, A.; Woollard, K. J.; Larsson, N.; et al. Integrated Proteomics Characterization of NLRP3 Inflammasome Inhibitor MCC950 in Monocytic Cell Line Confirms Direct MCC950 Engagement with Endogenous NLRP3. ACS Chemical Biology 2024, 19 (4), 962–972.