The focus of our research group at Duke University Medical Center is on the application of computational and mathematical methods to investigate physiology and pathophysiology of the nose, larynx and ear. In particular, we are interested in the development of clinically applicable algorithms that can efficiently identify the effects of pathological abnormality on functioning of the nose, larynx and ear. These algorithms will allow effective detection and diagnosis of airway diseases, as well as assist clinicians in determining objective and systematic treatment options that will optimize patient outcomes. Briefly, our primary interests in the nose are: [1] to study the impact of sinonasal diseases on nasal airflow dynamics, olfactory function, and intranasal drug delivery; and [2] to investigate the relationship between nasal cavity morphology and nasal function. Our research objectives in the larynx are to model laryngeal aerodynamic and aeroacoustic patterns in the healthy and pathological larynx, as well as to model topical drug deposition in the larynx. In the ear, we are interested in quantifying the influence of temporal bone anatomy both on hearing loss and on vestibular function.