The focus of our research group at Duke University Medical Center is on the application of computational and mathematical methods to investigate physiology and pathophysiology of the nose, larynx and ear. In particular, we are interested in the development of clinically applicable algorithms to efficiently identify the effects of pathological abnormality on functioning of the nose, larynx and ear. Such algorithms will permit efficient detection and diagnosis of airway diseases, as well as helping clinicians to determine objective and systematic treatment options to optimize patient outcomes. Briefly, our primary interests in the nose are:  the study of the impact of sinonasal diseases on nasal airflow dynamics, olfactory function, and intranasal drug delivery; and  investigation of the relationship between nasal cavity morphology and nasal function. Our research objectives in the larynx are to model laryngeal aerodynamic and aeroacoustic patterns in the healthy and pathological larynx, as well as to model topical drug deposition in the larynx. In the ear, we are interested in quantifying the influence of temporal bone anatomy both on hearing loss and on vestibular function.