Antibiotic Use in Acute Upper Respiratory Tract Infections – 12/27/2022 -We use too many antibiotics in an unnecessary fashion. One recent study of 15,000 patients treated with antibiotics found that 41% of the time, there was no indication for their use. Major groups recommend holding off on antibiotic use for mild to moderate sinusitis unless symptoms last for 10 or more days, or symptoms worsen after an initial period of improvement.
Note that 10% of the population report a penicillin allergy, though <1% actually have a confirmed penicillin allergy. Also, antibiotics are not typically helpful to treat laryngitis.
Clinical Practice Guideline by the Infectious Diseases Society of America: 2021 Focused Update Guidelines on Management of Clostridium difficile infection in Adults – 08/15/2022- Patients with severe disease (defined as WBC level > 15,000 or cr > 1.5) should ideally be treated with fidaxomicin. Alternatively, oral vancomycin can be used. The antibiotic associated with causing the infection should ideally be stopped.