Author: Kristianne Oristian

We are excited to share news of two grants supporting Alex Kovach’s work on the Role of the macro lncRNA KCNQIOT1 in Embryonal Rhabdomyosarcoma Tumorigenesis: An Innovation award from Alex’s Lemonade Stand and an award from The Kate Amato Foundation. We are grateful for the support of these foundations to pursue this exciting project!

In addition we continue to work with collaborators from here at Duke (Counter lab; Wood Lab), MIT, the Broad Institute, and also Mass General on an NIH-funded U54 Center for the Fusion Oncoproteins in Childhood Cancer Consortium (FusOnC2). You can read more about the projects here.

Stay tuned for more information and updates as we begin to work on these projects.

 

We are excited to share that our lab has had a productive academic year! Join us in celebrating these accomplishments.

The following grants have been awarded to our research group:

From The V Foundation-“Targeting the Hippo pathway in RAS-driven rhabdomyosarcoma (rERMS)”

From the Schiffman Foundation-“Use of 3D sphere cultures to investigate stemness properties of rhabdomyosarcoma”

From St. Baldrick’s Foundation (Research Award)- “Identification and validation of the PAX3-FOXO1 protein interactome”

From the Kate Amato Foundation-“Evaluation of the lncRNA KCNQ1OT1 and its binding proteins as pre-clinical therapeutic targets in embryonal rhabdomyosarcoma”

From Children’s Miracle Network Hospitals (Derfner Foundation Research Award, to Alex Kovach PhD)- “Preclinical evaluation of HES1 inhibition in the childhood cancer rhabdomyosarcoma”

The following papers have been accepted for publication:

RASSF4 is required for skeletal muscle differentiation. Lin YT, Deel MD, Linardic CM. Cell Biol Int. 2019 Sep 11. doi: 10.1002/cbin.11238.

Soft Tissue Sarcoma Cancer Stem Cells: An Overview. Genadry KC, Pietrobono S, Rota R, Linardic CM. Front Oncol. 2018 Oct 26;8:475. doi: 10.3389/fonc.2018.00475. eCollection 2018. Review.

Cheers to forward progress!

Congratulations to Corinne who received the Gordon G. Hammes Faculty Teaching Award at the Spring Faculty Meeting on May 8th! Read more about this well-deserved honor here. 

Special thanks to Dr. Lars Wagner, Division Chief, Pedatrics- Hematology/Oncology for accepting this award on Corinne’s behalf while she was speaking at the 2019 AACR Hippo Pathway conference.

Congratulations to Dr. Michael D. Deel who received an award from the V Foundation for Cancer Research in the amount of $200,000 for a study entitled “Investigating co-activator TAZ as a regulator of PAX3-FOXO1, cancer cell stemness, and chemoresistance in fusion-positive rhabdomyosarcoma.” Good work, Michael!

The Linardic Lab is grateful for the support of the Duke and Durham communities, and thrilled to announce that as a result of this support during our September 2018 Alex’s Million Mile campaign we have received a grant of $15, 021.00 from Alex’s Lemonade Stand Foundation! Thank you for continuing to believe in this research mission, and a special thanks to VWR, Tobacco Road Sports Cafe, and The Adam Dickinson Group at 501 Realty for their continued sponsorship.

Welcome to our shiny new laboratory website! Please “pardon our dust” as we begin to populate the site with new information about our lab. Thanks for visiting, and we look forward to hearing from you!