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Club EvMed: Evolution of diagnostic-resistant malaria in Africa

Wednesday, February 8th at 12pm EST/18:00 CET

Join us for a conversation with Jonathan Parr, Assistant Professor in the Division of Infectious Diseases at the University of North Carolina School of Medicine.

Increasing reports from Africa confirm emergence of malaria parasites with mutations that allow them to escape detection by widely used malaria diagnostic tests. These parasites threaten progress toward malaria elimination and have prompted a coordinated response by the WHO. Dr. Parr’s laboratory at UNC supports surveillance for these parasites across Africa and is applying novel sequencing approaches to study their evolution and spread.

Attendees are encouraged to read Feleke et al. 2021, “Plasmodium falciparum is evolving to escape malaria rapid diagnostic tests in Ethiopia” (doi: 10.1038/s41564-021-00962-4) and the WHO’s statement by the Malaria Policy Advisory Group on the urgent need to address the high prevalence of pfhrp2/3 gene deletions in the Horn of Africa and beyond.

Sign up here for the meeting link.

 

Club EvMed: Physiological implications of de novo gene emergence in health and disease

Tuesday, February 21st at 12pm EST/18:00 CET

Join us for a conversation with Anne-Ruxandra Carvunis, Associate Professor in Computational & Systems Biology at the University of Pittsburgh School of Medicine.

What makes each species unique? This seminar will discuss how thousands of small species-specific proteins contribute to molecular innovation in eukaryotes and the potential implications for human physiology in health and disease.

Attendees are encouraged to read Carvunis et al., 2012, “Proto-genes and de novo gene birth” (doi:10.1038/nature11184), Keeling et al., 2019, “The meanings of ‘function’ in biology and the problematic case of de novo gene emergence(doi:10.754/eLife.47014.001), and Mudge et al., 2022, “Standardized annotation of translated open reading frames” (doi:10.1038/s41587-022-01369-0). 

Sign up here for the meeting link.