We are excited to announce the next Club EvMed Conversation!
Thursday, February 12th at 12:30 EST
presented by Trevor Graham
in conversation with Michelle Lockley and Freddie Whiting
Opportunities to use evolutionary thinking to improve cancer treatment
Many cancer drugs give only a few months of benefit to patients. The reason for this is the evolution of drug resistance in the cancer. In this session we will discuss how evolutionary thinking might be able to help improve the drug discovery process (Freddie Whiting), and how the idea of evolutionary steering to forestall the evolution of resistance is being tested in clinical trials (Michelle Lockley). We will argue that evolution causes cancer treatments to fail, but that evolutionary thinking represents a rich opportunity to rapidly improve our cancer treatments.
We look forward to a robust discussion following the talk – join us!
Click here to register for this February 12th presentation.
For associated reading, please see the following papers:
- Quantitative measurement of phenotype dynamics during cancer drug resistance evolution using genetic barcoding (Nature Communications)
- Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv) (BMJ Open)
- Adaptive Therapy Exploits Fitness Deficits in Chemotherapy-Resistant Ovarian Cancer to Achieve Long-Term Tumor Control (Translational Cancer Biology)
Future Club EvMed Conversations will feature work presented by:
- Trevor Graham, Thursday, February 5th, 2026 at noon EST
- India Schneider-Crease, Monday, March 2, 2026 at noon EST
