Regulatory and Policy Science

Tobacco regulatory and policy science. Passage of the Family Smoking Prevention and Tobacco Control Act in 2009 granted the FDA authority to set new product standards for the manufacture, marketing and distribution of tobacco products. CfAST investigators are involved in several aspects of tobacco regulatory science that will influence FDA decision making and policy. As a site for the Center for Evaluation of Nicotine in Cigarettes (CENIC), CfAST is part of an ongoing, national trial to evaluate the effects of nicotine reduction in cigarettes on smoking behavior and toxicant exposure. In a similar study, we are currently evaluating the effects of nicotine reduction in cigarettes on smoking and psychiatric symptoms among smokers with ADHD. We are evaluating the effects of nicotine reduction and electronic cigarette (e-cigarette) use among other vulnerable populations including people living with HIV. Finally, in collaboration with public health experts at UNC and RTI, we are conducting pilot research on the influence of tobacco retail outlets and e-cigarette advertising on craving, tobacco purchasing and relapse.

Relevant publications:

Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG,al’Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML,Strasser AA, Tindle H, Hatsukami DK. Randomized Trial of Reduced-Nicotine Standards for Cigarettes. N Engl J Med. 2015 Oct;373(14):1340-9. PUBMED FULL TEXT

Current projects:

EFFECTS OF NICOTINE REDUCTION ON SMOKING BEHAVIOR IN ADHD SMOKERS R01HD083404 (PIs: Kollins, McClernon) NIH REPORTER

EVALUATING NEW NICOTINE STANDARDS FOR CIGARETTES U54DA031659 (PI: Eric Donny, Pittsburgh; Duke Site PI: McClernon) NIH REPORTER