Nicotine and non-nicotine factors

The role of nicotine and non-nicotine factors in tobacco addiction. Nicotine is the primary psychoactive substance in tobacco smoke. However, prior research has demonstrated that nicotine and nonnicotine factors play different roles in the initiation, use and relapse to tobacco smoking. CfAST researchers have conducted neuroimaging and behavioral pharmacology research to understand the influence of nicotine and nonnicotine factors on neurocognition and smoking reinforcement. In a recent, landmark study, we evaluated the effects of reducing nicotine levels in cigarettes on smoking behavior and are continuing to evaluate this question in ADHD and HIV-infected smokers.

Relevant Papers

McClernon FJ, Addicott MA, Sweitzer MM. Smoking abstinence and neurocognition:implications for cessation and relapse. Curr Top Behav Neurosci. 2015;23:193-227. PUBMED

Donny EC, Denlinger RL, Tidey JW, Koopmeiners JS, Benowitz NL, Vandrey RG,al’Absi M, Carmella SG, Cinciripini PM, Dermody SS, Drobes DJ, Hecht SS, Jensen J, Lane T, Le CT, McClernon FJ, Montoya ID, Murphy SE, Robinson JD, Stitzer ML,Strasser AA, Tindle H, Hatsukami DK. Randomized Trial of Reduced-Nicotine Standards for Cigarettes. N Engl J Med. 2015 Oct;373(14):1340-9. PUBMED FULL TEXT

Addicott MA, Froeliger B, Kozink RV, Van Wert DM, Westman EC, Rose JE,McClernon FJ. Nicotine and non-nicotine smoking factors differentially modulate craving, withdrawal and cerebral blood flow as measured with arterial spin labeling. Neuropsychopharmacology. 2014 Nov;39(12):2750-9. PUBMED

McClernon FJ, Froeliger B, Rose JE, Kozink RV, Addicott MA, Sweitzer MM, Westman EC, Van Wert DM. The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function. Addict Biol. 2015 Apr 22. PUBMED

Current Projects

EFFECTS OF NICOTINE REDUCTION ON SMOKING BEHAVIOR IN ADHD SMOKERS R01HD083404 (PIs: Kollins, McClernon) NIH REPORTER

EVALUATING NEW NICOTINE STANDARDS FOR CIGARETTES U54DA031659 (PI: Eric Donny, Pittsburgh; Duke Site PI: McClernon) NIH REPORTER