Decision Science Perspectives on Addiction. Drug use and other addictive behaviors involve making choices whether they or conscious or not. Smoking for instance involves making choices between the reward a smoker experiences by smoking balanced against the negative immediate (e.g. cost) and long term (e.g. cancer) negative consequences of smoking. CfAST investigators have used a number of approaches for investigating decision making in the context of addiction. Neuroimaging studies have been conducted to evaluate brain regions involved in valuation of drug and nondrug reward and the influence of nicotine on brain reward networks. Other studies have investigated explore vs. exploit tradeoffs as a novel framework for understanding tobacco use and other addictive behaviors (e.g. gambling).
Sweitzer MM, Geier CF, Denlinger R, Forbes EE, Raiff BR, Dallery J, McClernon FJ, Donny EC. Blunted striatal response to monetary reward anticipation during smoking abstinence predicts lapse during a contingency-managed quit attempt. Psychopharmacology (Berl). 2015 Dec 11. PUBMED
Addicott MA, Pearson JM, Kaiser N, Platt ML, McClernon FJ. Suboptimal foraging behavior: A new perspective on gambling. Behav Neurosci. 2015 Oct;129(5):656-65. PUBMED
Addicott MA, Pearson JM, Froeliger B, Platt ML, McClernon FJ. Smoking automaticity and tolerance moderate brain activation during explore-exploit behavior. Psychiatry Res. 2014 Dec 30;224(3):254-61. PUBMED
Sweitzer MM, Geier CF, Joel DL, McGurrin P, Denlinger RL, Forbes EE, Donny EC. Dissociated effects of anticipating smoking versus monetary reward in the caudate as a function of smoking abstinence. Biol Psychiatry. 2014 Nov 1;76(9):681-8. PUBMED FULL TEXT
Addicott MA, Pearson JM, Wilson J, Platt ML, McClernon FJ. Smoking and the bandit: a preliminary study of smoker and nonsmoker differences in exploratory behavior measured with a multiarmed bandit task. Exp Clin Psychopharmacol. 2013 Feb;21(1):66-73. PUBMED FULL TEXT
ACUTE AND CHRONIC NICOTINE MODULATION OF REINFORCEMENT LEARNING K01DA033347 (PI: Addicott) NIH REPORTER