Home » Claude D. Pepper Older Americans Independence Center (OAIC)

Claude D. Pepper Older Americans Independence Center (OAIC)

To understand and optimize reserve and resilience

NOTE: April 2017 -We are currently updating the Duke Pepper OAIC website. If you have questions, please contact us.

The overall goal of the Duke Claude D. Pepper Older Americans Independence Center (Duke OAIC) is to support research and training that improves the independence of older Americans. Our primary focus is understanding and optimizing reserve and resilience. Our approach is founded on the insight that independence in older adults is related to an individual’s ability to withstand or recover from functional decline following acute or chronic health stressors. Our overall strategy for the OAIC is to serve as a sustained resource to our investigators through a broad range of training and research studies; the goal will be to address knowledge gaps in our focus with an emphasis on translational and interdisciplinary research. We recruit and develop early stage investigators in aging research related to our focus and utilize the substantial strengths of the Duke academic and health system environment to advance our focus.

Our goals are accomplished through the synergistic activities of the Leadership and Administration Core (LAC), Research Education Component (REC), Pilot/Exploratory Studies Core (PESC), and 3 Resource Cores: Molecular Measures Core (MMC), Physical Measures Core (PMC), and Analysis Core (AC).

AIMS of the Duke Pepper Center
  1. To better understand and optimize reserve and resilience in older adults through an integrated research program.
  2. To develop and evaluate new methods that advance the study of reserve and resilience.
  3. To identify and develop the next generation of researchers who will become leaders in aging and geriatrics research related to the Duke OAIC focus.
  4. To support pilot studies through the PESC that acquire information needed to select or design successful, more definitive research studies related to the Duke OAIC focus.
Duke Pepper Scholar James White, PhD received a Poster Session award at the March 2017 National Pepper Centers meeting in Washington DC.Caloric Restriction Rescues Muscle Stem Cell Function through Induction of Autophagy
Frailty: Phenotype to Biology to Translation
Jeremy Walston, MD explored the concept of Frailty from cell to system perspectives and discussed current research to mitigate vulnerability in a Breakout Session at the National Pepper Centers meeting.

[Slide presentation]

Data Integration Working Group (DIWG)
The Duke Pepper Data Integration Working Group meets the 2nd and 4th Thursday of each month. The DIWG is open to members of the Duke community and is a wonderful inlet for individuals who want to learn more about the resources and opportunities of the Duke Pepper Center.
When: Thursday April 27, 2017 9:30-11:00am
Where: Learning Lab 1502 Blue Zone, Duke Clinics
Topic: Bill Kraus will present the MoTrPAC (Molecular Transducers of Physical Activity Consortium) project for which Duke is a clinical site and the Duke Stedman Metabolomics Lab is part of one of the Chemical Analysis sites.
Bill will present the basis for the project, the funding mechanism and the opportunity for ancillary studies.

Request For Pilot Study Proposals (2017)
In Summer 2017, the Pilot/Exploratory Studies Core will accept Funding Proposals for new Pilot Studies. Further information will be available here at that time.
In the News
AARP reports on PEPPER study from the Physical Measures Core which examines the relationship between aging, fitness and physical decline. [Read article]
Publication In Press
Belsky DW, Caspi A, Kraus W, Cohen HJ, Ramrakha S, Poulton R, Moffitt TE. “Impact of early personal-history characteristics on the Pace of Aging: Implications for clinical trials of therapies to slow aging and extend healthspan.” In Press, Aging Cell