To understand and optimize reserve and resilience
The overall goal of the Duke Claude D. Pepper Older Americans Independence Center (Duke OAIC) is to support research and training that improves the independence of older Americans. Our primary focus is understanding and optimizing reserve and resilience. Our approach is founded on the insight that independence in older adults is related to an individual’s ability to withstand or recover from functional decline following acute or chronic health stressors. Our overall strategy for the OAIC is to serve as a sustained resource to our investigators through a broad range of training and research studies; the goal will be to address knowledge gaps in our focus with an emphasis on translational and interdisciplinary research. We recruit and develop early stage investigators in aging research related to our focus and utilize the substantial strengths of the Duke academic and health system environment to advance our focus.
Our goals are accomplished through the synergistic activities of the Leadership and Administration Core (LAC), Research Education Component (REC), Pilot/Exploratory Studies Core (PESC), and 3 Resource Cores: Molecular Measures Core (MMC), Physical Measures Core (PMC), and Analysis Core (AC).
AIMS of the Duke Pepper Center
- To better understand and optimize reserve and resilience in older adults through an integrated research program.
- To develop and evaluate new methods that advance the study of reserve and resilience.
- To identify and develop the next generation of researchers who will become leaders in aging and geriatrics research related to the Duke OAIC focus.
- To support pilot studies through the PESC that acquire information needed to select or design successful, more definitive research studies related to the Duke OAIC focus.
New York Times Features Duke Pepper Center Researchers and 10-Year Legacy Effects of Exercise on Cardio-Metabolic Health Parameters
Duke Pepper researchers William Kraus, MD
and Kim Huffman, MD, PhD
, from the Molecular Measures Core, are among the authors of a study that looked at the legacy effects of exercise training interventions in participants from the STRRIDE (Studies Targeting Risk Reduction Interventions through Defined Exercise) protocol. Their research appears in the April issue of Frontiers of Physiology
and was recently featured in the New York Times
. Researchers found that vigorous intensity groups experienced less of a decrement in cardiorespiratory fitness than control or moderate intensity groups, and moderate intensity group members experienced the greatest 10-year reduction in fasting insulin and had greater reductions in mean arterial pressure. Their findings highlight the critical need to better understand the sustained legacy health effects of exercise training interventions.
[NY Times Article link]
[Frontiers in Physiology Article link]
[OVID link to original STRRIDE protocol]
Duke Pepper Center Researchers present PALS data at NCRC Catalyst Symposium
Duke Pepper researchers Daniel Parker, MD
, a geriatrician and Corey Simon, DPT, PhD
a member of the Duke Clinical Research Institute Musculoskeletal Team presented data from PALS, one of the only studies to measure physical function across the full adult lifespan. The study found that people in their 50s began to show deficits in strength and balance. Next, researchers will look at underlying biological mechanisms and hope to identify factors that are associated with maintenance or decline.
“PALS will help us understand factors associated with healthy aging and not-so-healthy aging,” Simon said. “How much is genetic, how much is lifestyle, how much is an inevitable fact of aging? These are things we hope to unravel.”
Meaningful Change Estimates for the Late-Life Function and Disability Instrument (LLFDI) in Older Adults: An Exploratory Study
A team of university and VA GRECC researchers performed a secondary analysis of the Boston Rehabilitative Impairment Study of the Elderly (RISE) in order to estimate the minimal clinically important difference (MCID) of the Late-Life Function and Disability Instrument-Function Component (LLFDI-FC) and its subscales among community-dwelling older adults with mobility limitations. The LLFDI-FC is a patient-reported measure of function. The MCID for each LLFDI-FC scale over 1 year of follow-up was estimated by a variety of methods. These estimates can assist clinicians and researchers of functional disability in the elderly.
Registration is Open NOW for the 2019 Pepper OAIC Annual Meeting (April 25th-26th)
NOTE: March 18th - Final Poster Abstract Submission Date!!
Registration is now open for the 2019 Pepper OAIC Annual Meeting on April 25th and 26th (Thurs/Fri) in Arlington VA. The Annual Meeting is especially relevant to early stage investigators. The Duke Pepper Center will prioritize Pepper scholars; i.e. REC scholars and Pilot study scholars. Three attendees will have the opportunity to present a poster of their work (NOTE: Two years ago, Duke Pepper Scholar James White received a top award for his presentation!). This year the meeting will feature an expanded Junior Faculty training component, as well as the ever popular Mock Study sections and Abstract presentations. If you working on a grant, the Annual Meeting is a great opportunity to have your grant reviewed by others. There is also a Junior/Senior match in which you can have one-on-one time with one of the many leading senior geriatrics researchers in the country.
February 8, 2019 ~ Early Bird Registration Deadline
March 1, 2019 ~ Junior Faculty Mock Study Submission Deadline
March 1-18, 2019 ~ Poster Abstract Submission Dates
March 27, 2019 ~ Hotel Sleep Room Block Cut-off Date (Renaissance Arlington Capital View)
Please contact your Core Leader or our Pepper Center directors (Ken Schmader/Miriam Morey) if you wish to attend. The schedule is essentially noon to noon, so it is very easy to attend the meeting as a single overnight meeting.
Duke Pepper Center Researchers Investigate Quantitative Muscle Ultrasound (QMUS) as an Alternative Reliable, Inexpensive Method to Measure Muscle Health
Muscle health is recognized for its critical role in the functionality and well-being of older adults. Duke Pepper researchers Lisa Hobson-Webb, MD
and Amy M. Pastva, PT, PhD
, along with the director of the Michael W. Krzyzewski Human Performance Lab, Timothy Sell, PT, PhD, examined the reliability of quantitative muscle ultrasound (QMUS), standard electrical impedance myography (sEIM), and handheld electrical impedance myography (hEIM) measures of anterior thigh musculature in the December 2018 Special Issue of Geriatrics: Geriatric Assessment: Multidimensional, Multidisciplinary and Comprehensive
. Multiple correlations with measures of strength and body composition were noted for each method. These point-of-care technologies may provide an alternative means of measuring health compared with more expensive traditional scan technologies.
Data Integration Working Group (DIWG) Semi-monthly (2nd and 4th Thursdays)
The Duke Pepper Data Integration Working Group meets the 2nd and 4th Thursday of each month. The DIWG is open to members of the Duke community and is a wonderful inlet for individuals who want to learn more about the resources and opportunities of the Duke Pepper Center.
: Thursday Apr 11th, 9:30-11:00am
: Learning Lab 1502 Blue Zone, Duke Clinics
: Gentzon Hall
: Understanding IL-15 in the aging kidney.
: Apr 25th: NO meeting: National Pepper Center meeting in Arlington, VA.
May 9th: Patrick Smith
: Aging SMART: Modified Trial Design Opportunities for Cognitive and Brain Health
Charlotte Observer Article Features Duke Pepper Center Research in MURDOCK Study
The Charlotte Observer recently featured the Duke Pepper Center’s PALS (Physical Performance Across the Life-Span) study in an in-depth article about the broader MURDOCK Study and the North Carolina Research Campus
in Kannapolis, NC. A video accompanying the article illustrates some of the physical skills tests for participants and features a 97-year old woman who did 11 sit-to-stands in 30 seconds!
Duke Pepper Center Researcher Stresses the Importance of Stored Biospecimen Research As Complementary Investigative Path With Long-Term Clinical Trials on Human Healthspan
Duke Pepper researcher Daniel Belsky, PhD
and Amal Harrati, PhD
, a Stanford researcher, discuss the relevance of biospecimen research in their article, To the freezers! Stored biospecimens from human randomized trials are an important new direction for studies of biological aging, in the January 2019 issue of The Journals of Gerontology, Biological Sciences & Medical Sciences
. Clinical trials testing effects on healthspan-relevant endpoints, like age-at-onset of chronic disease or disability, require many years or even decades of follow-up. While the field awaits a new generation of human trials of geroprotective therapies, analysis of stored biospecimens from now-completed studies can help test candidate surrogate endpoints in briefer research timeframes.
Duke Pepper Center Researchers Find Correlation Between Physical Activity and Physical Function in Persons 50 and Older Living With HIV/AIDS
Researchers from the Duke Pepper Center and the Duke Center for AIDS Research found that higher levels of physical activity were associated with better physical function in an older population of Persons Living with HIV/AIDS. This is believed to be the first study to examine these variables in this cohort. The researchers recommend that providers promote physical activity to improve physical performance in this population.
Duke Pepper Center Molecular Measures Core Co-Leader Receives Honorary Doctorate
Virginia Kraus, MD, PhD
, Professor of Medicine and Orthopedic Surgery, was awarded an honorary doctorate of the Faculty of Medicine and Life Sciences at the University of Tampere in Finland in August 2018. Dr Kraus also received a special hat and sword to protect the truth of science.
A rheumatologist, Dr Kraus leads large-scale research projects that are investigating the mechanisms of osteoarthritis, predicting the progression of the disease, and drug responses. Her research focuses on the early treatment of osteoarthritis (OA) before serious damage occurs.
Dr Kraus was also recognized for her mentorship to the next generation of researchers. She knows a few words in Finnish as a result of spending time in Finland as an exchange student.
Duke Pepper Center Researchers Investigate Relationships of SES and Physical Functioning
Duke Pepper researchers, led by Grace Noppert, PhD
, examined associations between multiple early and late life SES indicators with physical function. The research team discovered higher participant education and household income were associated with increased physical function. In an age-stratified analysis, SES disparities widened with increasing age among those in the two younger strata: lower SES was associated with worse physical function. Their findings highlight the significance of considering multiple dimensions of the social environment as important correlates of physical functioning over the life course.
Duke Pepper Center Physical Measures Core Co-Leader Investigates Benefits of Exercise in Older Vets with PTSD
Katherine S. Hall, PhD
, Assistant Professor in the Division of Geriatrics, is launching a pilot study to learn if increased physical activity among older Vets with PTSD will help ease their symptoms. Veterans with PTSD have been shown to have low rates of exercise, and many report that they don’t work out at all. The heart of the study is a supervised 12-week exercise plan called the “Warrior Wellness” program. It consists of activities focusing on strength, flexibility, balance, and endurance training. Part of what makes the program special is its extensive exercise battery that can be adapted to individual musculoskeletal ailments.
Duke Pepper Center Researcher Receives K23 Funding
Richard Lee, MD
, Assistant Professor of Medicine in Endocrinology, Metabolism, and Nutrition, and a former Duke Pepper Center Scholar, received an award (1K23-AG058797-01) from the National Institutes of Health for a project entitled “Metabolomic & Radiographic Markers of Fracture Risk among Older Adults with Diabetes.” Total funding, announced in April 2018, will be $541,667.
Duke Pepper Center Core Leaders Receive Leadership and Research Honors
Cathleen Colón-Emeric, MD, MHS
, Co-Leader of the Research Education Component
of the Duke Pepper Center, has been appointed associate dean for research mentoring for the School of Medicine. Dr. Colon-Emeric will lead two existing grant programs, the K-Club (to assist faculty writing career development awards) and the Path to Independence Program (to assist faculty writing their first R-grant).
Kenneth Schmader, MD
, Director of the Leadership and Administration Core
, is the 2018 recipient of the American Society for Clinical Pharmacology and Therapeutics William B. Abrams Award in Geriatric Clinical Pharmacology. The award recognizes scientists who have improved clinical care or therapies for older adults through research and honors an investigator in geriatric clinical pharmacology for outstanding contributions to the field.
Duke Pepper Center hosts Spring 2018 workshop: Physical Function Assessment in Older Adults
The Duke Pepper Physical Measures Core
hosted a half-day workshop
in May which highlighted functional assessments that can be utilized across the continuum of functional ability and implemented across a variety of settings (e.g., resource-rich vs. resource-limited, outpatient vs. inpatient). Participants came from several departments within the School of Medicine and the Health System to gain more knowledge and practical expertise in the implementation of performance-based measures of physical function in research.
Duke Pepper Center Research Posters at the 2018 Pepper OAIC Annual Meeting
An Innovative Approach to Building Posttraumatic Resilience in Late Life: The Warrior Wellness Exercise Study for Older Veterans with PTSD Poster Presentation Award
Katherine S. Hall, PhD
, and her colleagues summarized the current status of the Warrior Wellness Study, a randomized controlled exercise trial for older veterans with PTSD. If the Warrior Wellness intervention is found to be effective at helping older veterans with PTSD improve resilience and achieve physical and psychological outcomes, this group-based exercise program could be expanded and implemented into clinical practice.
Age-Related Adverse Inflammatory and Metabolic Changes Begin Early in Adulthood
Daniel Parker, MD
, and his team presented cross-sectional data which demonstrate the onset – as early as the fourth decade of age – of abnormalities of immune and metabolic biomarkers known to be associated with impaired physical function, morbidity, and mortality in older adults.
Macrophage-induced Meteorin-like secretion: A potential regenerative therapy for aging muscle
James P. White, PhD
, and a research team across institutions presented studies that identified Meteorin-like (Metrnl) as a critical regulator in muscle regeneration and a viable therapeutic to enhance regeneration in aged muscle.