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Search Results for: Duke Family Support Program
The Behavior and Physiology in Aging – Research Training Program
Claude D. Pepper Older American Independence Center (OAIC)
Duke Dementia Family Support Program
Center for Spirituality, Theology, and Health
Computing and Statistical Laboratory
Chinese Longitudinal Healthy Longevity Survey (CLHLS)
Research Participant Registry
The Behavior and Physiology in Aging – Research Training Program, funded by NIH for the past 32 years, supports postdoctoral fellows with career interests in aging who train in Duke research programs in which aging research is ongoing. Areas of interest may include medical anthropology, exercise physiology, psychology, and nursing. Fellows attend weekly seminars in the biomedical, social, and psychological aspects of aging as well as in professional development. An important component of the seminar is the annual research ethics modul
The Claude D. Pepper Older American Independence Center (OAIC) with funding by NIA, focuses on understanding and treating dysmobility associated with aging. Following the first designation of the Aging Center as Pepper Center in 1992, the second Pepper Center grant, awarded in 1999, included cores that provided service to other funded research projects, as well as to Pepper-specific projects. A third Pepper Center grant, awarded in 2006, is exploring approaches to understanding and modifying multiple pathways of functional decline through research and faculty development. In collaboration with various Duke departments, divisions, and centers, the OAIC supports mentored research of junior faculty; pilot research projects; an analysis core; a biological studies core; and developmental projects in biomarkers, metabolomics, and database development.
The Duke Dementia Family Support Program provides the following free services to all North Carolina residents: confidential, personalized tips on caring for people with memory disorders; a comprehensive information packet on Alzheimer’s disease and a Caregiver newsletter delivered twice a year; telephone help with care decisions, coping strategies and evaluating service or residential care options as well as help selecting support groups, education programs, online information or books.
The Center for Spirituality, Theology, and Health, in collaboration with the Center for the Study of Aging, has received two awards from the John Templeton Foundation to: 1) solicit, award and coordinate seven research projects which would investigate how religion/spirituality influences individual and community health, and 2) form and maintain a community of scholars, build network of senior and junior researchers in spirituality, theology and health.
The Computing and Statistical Laboratory operated by the Center permits easy access to large data bases and statistical analysis software packages. Both faculty and trainees can also access this facility through personal and laptop computers throughout the building or via modem or DSL facilities from other campus locations or at home. Statistical support to aid investigators and trainees in planning studies, analyzing data and learning how to use statistical software packages is also available in the computing laboratory. This expert statistical assistance is freely available and given in a one-on-one tutorial basis so that trainees and faculty can learn to develop the most appropriate study designs and use the most effective data analysis programs available.
My research interests over thirty-five years at the Duke Center for Aging have evolved from early studies with Drs. Linda George and Elizabeth Clipp of the emotional, physical and financial consequences of caring for a family member with dementia, to evaluating outcomes of dementia-specific care practices such as providing trained in-home respite care workers and individualized family education to reduce negative mental health effects of providing family dementia care. Later, I collaborated on National Institute on Aging multi-site studies of the effectiveness, benefits and limits of Alzheimer’s special care units in nursing homes, culminating in a collaboration with UNC Sheps Center investigators titled “Families Matter in Long-Term Care”, a group randomized trial funded by the National Institute on Aging. “Families Matter” was designed to help families work with staff and residents to create a role for themselves that would benefit the resident’s quality of life and improve family/staff relations. The paper published in the journal, Seniors Housing and Care, won the journal’s Outstanding Research Paper award.
Families of assisted living and nursing home residents were helped to develop plans for their visits which included activities categorized as “doing things”, “getting around”, “looking good” and “eating well”. Families of residents with dementia did not differ in their frequency of visits from other families, but they spent more time on nutrition, mobility and discussing care with staff. Overall, the program decreased family burden and improved resident quality of life. Residential care staff also reported less burnout and greater partnership with families. However, personal care staff reported greater burden and frustration and felt less in partnership and more controlling by families than their supervisors. We learned that creating, roles for families may foster a greater sense of responsibility, but perhaps a concomitant realization that they hadn’t been doing as much as they could or should, which resulted in increased family guilt and conflict.
Currently, I am working with Bobbi Matchar, MSW from the Duke Family Support Program on the “Alzheimer’s Medical Advisor” project funded by the National Institute of Nursing Research, led by UNC geriatrician, Dr. Philip Sloane, with team members from the UNC Sheps Center.
When people with Alzheimer’s disease or related dementias develop new symptoms, such as cough, abdominal pain, or fever, their family caregivers must decide whether the problem is minor enough to try treating at home, or whether to go to a physician’s office or the emergency department. This can be challenging when the person with dementia has difficulty communicating accurately how s/he feels or resists going to an office visit or evaluations by medical professionals. Families need tools to help them evaluate and manage symptoms that could represent new or evolving medical illness in a family member with Alzheimer’s disease.
The “Alzheimer’s Medical Advisor” is a series of materials in development to help family caregivers of persons with dementia deal with these issues. It consists of internet-based, written, and video tools to help concerned family understand, identify, communicate with health professionals, and make decisions about medical problems. The materials will: 1) inform families about common medical problems experienced by persons with dementia; 2) help family caregivers decide what to do next when their family member has a new or exacerbated medical problem; new physical symptom; 3) provide a way to record and communicate information that doctors want to know; and 4) provide home care tips for common medical conditions in persons with dementia.
Please take some time to view the History of the Center, compiled by George L. Maddox, Ph.D., below in whole and in its parts.
Lisa Gwyther, MSW, education director at Duke University’s Alzheimer’s Disease Research Center was quoted in the June 21, 2015, issue of Parade magazine as saying
“A lot of unmet needs are being responded to spontaneously – to fill the needs for inclusion, for less stigma about the disease and for more focus on quality of life.”
The quote was in an article by Paula Spencer Scott on “People Power: How grassroots campaigns are easing the burden of caring for someone with Alzheimer’s—and improving patient quality of life.”
The articles also says,
“After social worker Bobbi Matchar held an eight week education program at Duke University for people recently diagnosed and their care partners, the group grew so close nobody wanted it to end. So they called themselves ‘the Alphas’ and three years later, still meet monthly at a local restaurant, along with later graduates of the Duke class. ‘It creates a sense of community among people who didn’t choose to have the situation and who often have to quit their old communities at work and church,’ says Matchar.”
Matchar, MSW, is an assistant to Gwyther in the Duke Family Support Program.
JOURNAL ARTICLES, BOOKS, AND BOOK CHAPTERS PUBLISHED
Through June 2016
Bartlett DB, Connelly MA, AbouAssi H, Bateman LA, Tune KN, Huebner JL, Kraus VB, Winegar DA, Otvos JD, Kraus WE, Huffman KM. A novel inflammatory biomarker, GlycA, associates with disease activity in rheumatoid arthritis and cardio-metabolic risk in BMI-matched controls. Arthritis Res Ther. 2016 Apr 12;18:86. [PMC free article] [PubMed]
Catterall JB, Zura RD, Bolognesi MP, Kraus VB. Aspartic acid racemization reveals a high turnover state in knee compared with hip osteoarthritic cartilage. Osteoarthritis Cartilage. 2016 Feb;24(2):374-81. [PMC free article] [PubMed]
Chen S, Whitson H, Quiñones A, Thielke S. Comparative health and self-rated health are equivalently associated with health indicators among older adults. J Clin Epidemiol 2016 Feb;70:279-280. [PMC free article] [PubMed]
Cohen HJ, Walston JD, Rao SV, Schrier SL, Artz A. Partnership for Anemia: Clinical and Translational Trials in the Elderly Consortium. Renal Toxicity Associated with Salsalate in Elderly Adults with Anemia. J Am Geriatr Soc 2016 Apr;64(4):898-899. [PMC free article] [PubMed]
Dungan JR, Qin X, Horne BD, Carlquist JF, Singh A, Hurdle M, Grass E, Haynes C, Gregory SG, Shah SH, Hauser ER, Kraus WE. Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship. PLoS One. 2016 May 17;11(5):e0154856. [PMC free article] [PubMed]
Hybels CF, Pieper CF, Payne ME, Steffens DC. Late-life Depression Modifies the Association Between Cerebral White Matter Hyperintensities and Functional Decline Among Older Adults. Am J Geriatr Psychiatry 2016 Jan;24(1):42-49. [PMC free article] [PubMed]
Jamerson BD, Fillenbaum GG, Sloane R, Morey MC. A new method for identifying characteristics of needing help to take medications in an older representative community-resident population: the Older Adults Medication Assist Scale. J Am Geriatr Soc 2016 Jun; 64(6):1195–1202. Minority Research Publication [PMC free article] [PubMed]
Johnson KS, Payne R, Kuchibhatla MN. What are Hospice Providers in the Carolinas Doing to Reach African Americans in Their Service Area? J Palliat Med. 2016 Feb;19(2):183-189. Minority Research Publication [PMC free article] [PubMed]
LaFleur J, Rillamas-Sun E, Colón-Emeric CS, Knippenberg KA, Ensrud KE, Gray SL, Cauley JA, LaCroix AZ. Fracture Rates and Bone Density Among Postmenopausal Veteran and Non-Veteran Women From the Women’s Health Initiative. Gerontologist. 2016 Feb;56 Suppl 1:S78-90. [PMC free article] [PubMed]
Lee RH, Pearson M, Lyles KW, Jenkins PW, Colon-Emeric C. Geographic scope and accessibility of a centralized, electronic consult program for patients with recent fracture. Rural Remote Health 2016 Jan-Mar;16(1):3440. [PMC free article] [PubMed]
Lv YB, Yin ZX, Chei CL, Brasher MS, Zhang J, Kraus VB, Qian F, Shi XM, Matchar DB, Zeng Y. Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly. J Nutr Health Aging. 2016 Mar;20(3):280-7. [PMC free article] [PubMed]
McClain MT, Nicholson BP, Park LP, Liu TY, Hero AO 3rd, Tsalik EL, Zaas AK, Veldman T, Hudson LL, Lambkin-Williams R, Gilbert A, Burke T, Nichols M, Ginsburg GS, Woods CW. A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses. Open Forum Infect Dis. 2016 Jan 19;3(1):ofw007. [PMC free article] [PubMed]
McGarrah RW, Craig DM, Haynes C, Dowdy ZE, Shah SH, Kraus WE. High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort. Atherosclerosis. 2016 Mar;246:229-35. [PMC free article] [PubMed]
Peterson MJ, Thompson DK, Pieper CF, Morey MC, Kraus VB, Kraus WE, Sullivan P, Fillenbaum G, Cohen HJ. A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span. J Gerontol A Biol Sci Med Sci 2016 Feb;71(2):196-202. [PMC free article] [PubMed]
Potter GG, McQuoid DR, Whitson HE, Steffens DC. Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions. Int J Geriatr Psychiatry 2016 May;31(5):466-474. [PMC free article] [PubMed]
Povsic TJ, Sloane R, Pieper CF, Pearson MP, Peterson ED, Cohen HJ, Morey MC. Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study. J Gerontol A Biol Sci Med Sci. 2016 Mar;71(3):362-9. [PMC free article] [PubMed]
Stiber JA, Wu JH, Zhang L, Nepliouev I, Zhang ZS, Bryson VG, Brian L, Bentley RC, Gordon-Weeks PR, Rosenberg PB, Freedman NJ. The Actin-Binding Protein Drebrin Inhibits Neointimal Hyperplasia. Arterioscler Thromb Vasc Biol. 2016 May;36(5):984-93. [PMC free article] [PubMed]
Toles M, Colón-Emeric C, Naylor MD, Barroso J, Anderson RA. Transitional care in skilled nursing facilities: a multiple case study. BMC Health Serv Res. 2016 May 17;16:186. [PMC free article] [PubMed]
Whitson HE, Duan-Porter W, Schmader KE, Morey MC, Cohen HJ, Colón-Emeric CS. Physical Resilience in Older Adults: Systematic Review and Development of an Emerging Construct. J Gerontol A Biol Sci Med Sci 2016 Apr;71(4):489-495. [PMC free article] [PubMed]
Zeng Y, Nie C, Min J, Liu X, Li M, Chen H, Xu H, Wang M, Ni T, Li Y, Yan H, Zhang JP, Song C, Chi LQ, Wang HM, Dong J, Zheng GY, Lin L, Qian F, Qi Y, Liu X, Cao H, Wang Y, Zhang L, Li Z, Zhou Y, Wang Y, Lu J, Li J, Qi M, Bolund L, Yashin A, Land KC, Gregory S, Yang Z, Gottschalk W, Tao W, Wang J, Wang J, Xu X, Bae H, Nygaard M, Christiansen L, Christensen K, Franceschi C, Lutz MW, Gu J, Tan Q, Perls T, Sebastiani P, Deelen J, Slagboom E, Hauser E, Xu H, Tian XL, Yang H, Vaupel JW. Novel loci and pathways significantly associated with longevity. Sci Rep. 2016 Feb 25;6:21243. [PMC free article] [PubMed]
Zullig LL, Whitson HE, Hastings SN, Beadles C, Kravchenko J, Akushevich I, Maciejewski ML. A Systematic Review of Conceptual Frameworks of Medical Complexity and New Model Development. J Gen Intern Med 2016 Mar;31(3):329-337. [PMC free article] [PubMed]
Adams RN, Mosher CE, Blair CK, Snyder DC, Sloane R, Demark-Wahnefried W. Cancer survivors’ uptake and adherence in diet and exercise intervention trials: an integrative data analysis. Cancer. 2015 Jan 1;121(1):77-83. [PMC free article] [PubMed]
Band PA, Heeter J, Wisniewski HG, Liublinska V, Pattanayak CW, Karia RJ, Stabler T, Balazs EA, Kraus VB. Hyaluronan molecular weight distribution is associated with the risk of knee osteoarthritis progression. Osteoarthritis Cartilage 2015 Jan;23(1):70-76. [PMC free article] [PubMed]
Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE. Quantification of biological aging in young adults. Proc Natl Acad Sci U S A 2015 Jul 28;112(30):E4104-4110. [PMC free article] [PubMed]
Belsky DW, Caspi A, Israel S, Blumenthal JA, Poulton R, Moffitt TE. Cardiorespiratory fitness and cognitive function in midlife: neuroprotection or neuroselection? Ann Neurol 2015;77(4):607-617. [PMC free article] [PubMed]
Berger M, Nadler JW, Browndyke J, Terrando N, Ponnusamy V, Cohen HJ, Whitson HE, Mathew JP. Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly. Anesthesiol Clin 2015 Sep;33(3):517-550. [PMC free article] [PubMed]
Blay SL, Fillenbaum GG, Peluso ET. Differential characteristics of young and midlife adult users of psychotherapy, psychotropic medications, or both: information from a population representative sample in Sao Paulo, Brazil. A cross-sectional study. BMC Psychiatry 2015; 15:268. [PMC free article] [PubMed]
Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin AR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AM, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HP, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HM, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M. Designing a broad-spectrum integrative approach for cancer prevention and treatment. Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304. [PMC free article] [PubMed]
Brenes-Salazar JA, Alshawabkeh L, Schmader KE, Hanlon JT, Forman DE. Clinical pharmacology relevant to older adults with cardiovascular disease. J Geriatr Cardiol 2015 May;12(3):192-195. [PMC free article] [PubMed]
Chou CH, Lee MT, Song IW, Lu LS, Shen HC, Lee CH, Wu JY, Chen YT, Kraus VB, Wu CC. Insights into osteoarthritis progression revealed by analyses of both knee tibiofemoral compartments. Osteoarthritis Cartilage 2015 Apr;23(4):571-580. [PubMed]
Fu Q, Cao J, Renner JB, Jordan JM, Caterson B, Duance V, Luo M, Kraus VB. Radiographic features of hand osteoarthritis in adult Kashin-Beck Disease (KBD): the Yongshou KBD study. Osteoarthritis Cartilage 2015 Jun;23(6):868-873. [PMC free article] [PubMed]
Genao L, Durheim MT, Mi X, Todd JL, Whitson HE, Curtis LH. Early and Long-term Outcomes of Older Adults after Acute Care Encounters for Chronic Obstructive Pulmonary Disease Exacerbation. Ann Am Thorac Soc 2015 Dec;12(12):1805-1812. [PMC free article] [PubMed]
Hall RK, Landerman LR, O’Hare AM, Anderson RA, Colón-Emeric CS. Chronic kidney disease and recurrent falls in nursing home residents: a retrospective cohort study. Geriatr Nurs. 2015 Mar-Apr;36(2):136-141. Minority Research Publication [PMC free article] [PubMed]
Hall RK, Toles M, Massing M, Jackson E, Peacock-Hinton S, O’Hare AM, Colón-Emeric C. Utilization of acute care among patients with ESRD discharged home from skilled nursing facilities. Clin J Am Soc Nephrol. 2015 Mar 6;10(3):428-434. Minority Research Publication [PMC free article] [PubMed]
Huang Z, Ma J, Chen J, Shen B, Pei F, Kraus VB. The effectiveness of low-level laser therapy for nonspecific chronic low back pain: a systematic review and meta-analysis. Arthritis Res Ther 2015 Dec 15;17:360. [PMC free article] [PubMed]
Huffman KM, Pieper CF, Hall KS, St Clair EW, Kraus WE. Self-efficacy for exercise, more than disease-related factors, is associated with objectively assessed exercise time and sedentary behaviour in rheumatoid arthritis. Scand J Rheumatol 2015;44(2):106-110. [PMC free article] [PubMed]
Hybels CF, Pieper CF, Payne ME, Steffens DC. Late-life depression modifies the association between cerebral white matter hyperintensities and functional decline among older adults. American Journal of Geriatric Psychiatry 2016;24:42-49. [PMC free article] [PubMed]
Kannan S, Kossenkov A, Kurupati RK, Xiang JZ, Doyle SA, Schmader KE, Schowe L, Ertl HC. A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged. Aging (Albany NY) 2015 Dec;7(12):1077-1085. [PMC free article] [PubMed]
Kannan S, Kurupati RK, Doyle SA, Freeman GJ, Schmader KE, Ertl HC. BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine. Oncotarget 2015 Aug 14;6(23):19445-19455. [PMC free article] [PubMed]
Kenzik KM, Morey MC, Cohen HJ, Sloane R, Demark-Wahnefried W. Symptoms, weight loss, and physical function in a lifestyle intervention study of older cancer survivors. J Geriatr Oncol 2015 Nov;6(6):424-432. [PMC free article] [PubMed]
Kraus VB, Blanco FJ, Englund M, Karsdal MA, Lohmander LS. Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use. Osteoarthritis Cartilage 2015 Aug;23(8):1233-1241. [PMC free article] [PubMed]
Kraus VB, Blanco FJ, Englund M, Henrotin Y, Lohmander LS, Losina E, Önnerfjord P, Persiani S. OARSI Clinical Trials Recommendations: Soluble biomarker assessments in clinical trials in osteoarthritis. Osteoarthritis Cartilage 2015 May;23(5):686-697. [PMC free article] [PubMed]
Lee RH, Pieper CF, Colón-Emeric C. Functional Impairments Mediate Association Between Clinical Fracture Risk and Type 2 Diabetes Mellitus in Older Women. J Am Geriatr Soc. 2015 Aug;63(8):1546-51. [PMC free article] [PubMed]
Lv YB, Yin ZX, Chei CL, Qian HZ, Kraus VB, Zhang J, Brasher MS, Shi XM, Matchar DB, Zeng Y. Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey. Atherosclerosis. 2015 Mar;239(1):137-142. [PMC free article] [PubMed]
Morey MC, Blair CK, Sloane R, Cohen HJ, Snyder DC, Demark-Wahnefried W. Group trajectory analysis helps to identify older cancer survivors who benefit from distance-based lifestyle interventions. Cancer 2015 Dec 15;121(24):4433-4440. [PMC free article] [PubMed]
Pearce MJ, Koenig HG, Robins CJ, Nelson B, Shaw SF, Cohen HJ, King MB. Religiously integrated cognitive behavioral therapy: a new method of treatment for major depression in patients with chronic medical illness. Psychotherapy (Chic) 2015 Mar;52(1):56-66. [PMC free article] [PubMed]
Povsic TJ, Sloane R, Pieper CF, Pearson MP, Peterson ED, Cohen HJ, Morey MC. Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study. J Gerontol A Biol Sci Med Sci 2016 Mar;71(3):362-369. [PMC free article] [PubMed]
Souza AM, Fillenbaum GG, Blay SL. Prevalence and correlates of physical inactivity among older adults in Rio Grande do Sul, Brazil. PLoS One. 2015;10(2):e0117060. Minority Research Publication [PMC free article] [PubMed]
Whitson HE, Chou YH, Potter GG, Diaz MT, Chen NK, Lad EM, Johnson MA, Cousins SW, Zhuang J, Madden DJ. Phonemic fluency and brain connectivity in age-related macular degeneration: a pilot study. Brain Connect. 2015 Mar;5(2):126-135. [PMC free article] [PubMed]
Zeng Y, Chen H, Ni T, Ruan R, Feng L, Nie C, Cheng L, Li Y, Tao W, Gu J, Land KC, Yashin A, Tan Q, Yang Z, Bolund L, Yang H, Hauser E, Willcox DC, Willcox BJ, Tian XL, Vaupel JW. GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):426-433. [PMC free article] [PubMed]
Aslam I, Perjar I, Shi XA, Renner JB, Kraus VB, Golightly YM, Jordan JM, Nelson AE. Associations between biomarkers of joint metabolism, hand osteoarthritis, and hand pain and function: the Johnston County Osteoarthritis Project. J Rheumatol. 2014 May;41(5):938-944. Minority Research Publication [PMC free article] [PubMed]
Belsky DW, Shalev I, Sears MR, Hancox RJ, Lee Harrington H, Houts R, Moffitt TE, Sugden K, Williams B, Poulton R, Caspi A. Is chronic asthma associated with shorter leukocyte telomere length at midlife? Am J Respir Crit Care Med. 2014 Aug 15;190(4):384-391. [PMC free article] [PubMed]
Belsky DW, Suppli NP, Israel S. Gene-environment interaction research in psychiatric epidemiology: a framework and implications for study design. Soc Psychiatry Psychiatr Epidemiol. 2014 Oct;49(10):1525-1529. [PMC free article] [PubMed]
Blair CK, Morey MC, Desmond RA, Cohen HJ, Sloane R, Snyder DC, Demark-Wahnefried W. Light-intensity activity attenuates functional decline in older cancer survivors. Med Sci Sports Exerc. 2014 Jul;46(7):1375-1383. [PMC free article] [PubMed]
Blay SL, Fillenbaum GG, da Silva PF, Peluso ET. Use of psychotherapy in a representative adult community sample in São Paulo, Brazil. J Nerv Ment Dis. 2014 Sep;202(9):688-694. [PMC free article] [PubMed]
Blay SL, Fillenbaum GG, Pitta JC, Peluso ET. Factors associated with antidepressant, anxiolytic, and other psychotropic medication use to treat psychiatric symptoms in the city of São Paulo, Brazil. Int Clin Psychopharmacol. 2014 May;29(3):157-165. [PMC free article] [PubMed]
Clark N, Fan VS, Slatore CG, Locke E, Whitson HE, Nici L, Thielke SM. Dyspnea and pain frequently co-occur among Medicare managed care recipients. Ann Am Thorac Soc. 2014 Jul;11(6):890-897. [PMC free article] [PubMed]
Hastings SN, Sloane R, Morey MC, Pavon JM, Hoenig H. Assisted early mobility for hospitalized older veterans: preliminary data from the STRIDE program. J Am Geriatr Soc. 2014 Nov;62(11):2180-2184. [PMC free article] [PubMed]
Herati RS, Reuter MA, Dolfi DV, Mansfield KD, Aung H, Badwan OZ, Kurupati RK, Kannan S, Ertl H, Schmader KE, Betts MR, Canaday DH, Wherry EJ. Circulating CXCR5+PD-1+ response predicts influenza vaccine antibody responses in young adults but not elderly adults. J Immunol. 2014 Oct 1;193(7):3528-3537. [PMC free article] [PubMed]
Huffman KM, Koves TR, Hubal MJ, Abouassi H, Beri N, Bateman LA, Stevens RD, Ilkayeva OR, Hoffman EP, Muoio DM, Kraus WE. Metabolite signatures of exercise training in human skeletal muscle relate to mitochondrial remodelling and cardiometabolic fitness. Diabetologia. 2014 Nov;57(11):2282-2295. [PMC free article] [PubMed]
Hunter DJ, Nevitt M, Losina E, Kraus V. Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol. 2014 Feb;28(1):61-71. [PMC free article] [PubMed]
Hsueh MF, Önnerfjord P, Kraus VB. Biomarkers and proteomic analysis of osteoarthritis. Matrix Biol. 2014 Oct;39:56-66. [PubMed]
Hybels CF, George LK, Blazer DG, Pieper CF, Cohen HJ, Koenig HG. Inflammation and Coagulation as Mediators in the Relationships Between Religious Attendance and Functional Limitations in Older Adults. J Aging Health. 2014 Jun 26(4):679-697. [PMC free article] [PubMed]
Israel S, Caspi A, Belsky DW, Harrington H, Hogan S, Houts R, Ramrakha S, Sanders S, Poulton R, Moffitt TE. Credit scores, cardiovascular disease risk, and human capital. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17087-17092. [PMC free article] [PubMed]
Itty S, Day S, Lyles KW, Stinnett SS, Vajzovic LM, Mruthyunjaya P. Vitamin D deficiency in neovascular versus nonneovascular age-related macular degeneration. Retina. 2014 Sep;34(9):1779-1786. [PMC free article] [PubMed]
Kitzman DW, Nicklas B, Kraus WE, Lyles MF, Eggebeen J, Morgan TM, Haykowsky M. Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. Am J Physiol Heart Circ Physiol. 2014 May;306(9):H1364-1370. [PMC free article] [PubMed]
Lee RH, Lyles KW, Pearson M, Barnard K, Colón-Emeric C. Osteoporosis screening and treatment among veterans with recent fracture after implementation of an electronic consult service. Calcif Tissue Int. 2014 Jun;94(6):659-664. [PMC free article] [PubMed]
Nelson AE, Elstad E, DeVellis RF, Schwartz TA, Golightly YM, Renner JB, Conaghan PG, Kraus VB, Jordan JM. Composite measures of multi-joint symptoms, but not of radiographic osteoarthritis, are associated with functional outcomes: the Johnston County Osteoarthritis Project. Disabil Rehabil. 2014;36(4):300-306. [PMC free article] [PubMed]
Orlowsky EW, Stabler TV, Montell E, Vergés J, Kraus VB. Monosodium urate crysta induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis? BMC Musculoskelet Disord. 2014 Sep 27;15:318. [PMC free article] [PubMed]
Scholtens DM, Muehlbauer MJ, Daya NR, Stevens RD, Dyer AR, Lowe LP, Metzger BE, Newgard CB, Bain JR, Lowe WL Jr; HAPO Study Cooperative Research Group. Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care. 2014 Jan;37(1):158-166. [PMC free article] [PubMed]
Shalev I, Caspi A, Ambler A, Belsky DW, Chapple S, Cohen HJ, Israel S, Poulton R, Ramrakha S, Rivera CD, Sugden K, Williams B, Wolke D, Moffitt TE. Perinatal complications and aging indicators by midlife. Pediatrics. 2014 Nov;134(5):e1315-1323. [PMC free article] [PubMed]
Whitson HE, Arnold AM, Yee LM, Mukamal KJ, Kizer JR, Djousse L, Ix JH, Siscovick D, Tracy RP, Thielke SM, Hirsch C, Newman AB, Zieman S. Serum carboxymethyl-lysine, disability, and frailty in older persons: the Cardiovascular Health Study. J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):710-716. [PMC free article] [PubMed]
Whitson HE, Malhotra R, Chan A, Matchar DB, Østbye T. Comorbid visual and cognitive impairment: relationship with disability status and self-rated health among older Singaporeans. Asia Pac J Public Health. 2014 May;26(3):310-319. [PMC free article] [PubMed]
Winger JG, Mosher CE, Rand KL, Morey MC, Snyder DC, Demark-Wahnefried W. Diet and exercise intervention adherence and health-related outcomes among older long-term breast, prostate, and colorectal cancer survivors. Ann Behav Med. 2014 Oct;48(2):235-245. [PMC free article] [PubMed]
Wisniewski HG, Colón E, Liublinska V, Karia RJ, Stabler TV, Attur M, Abramson SB, Band PA, Kraus VB. TSG-6 activity as a novel biomarker of progression in knee osteoarthritis. Osteoarthritis Cartilage. 2014 Feb;22(2):235-241. [PMC free article] [PubMed]
Yin Z, Shi X, Kraus VB, Brasher MS, Chen H, Liu Y, Lv Y, Zeng Y. Gender-dependent association of body mass index and waist circumference with disability in the Chinese oldest old. Obesity (Silver Spring). 2014 Aug;22(8):1918-1925. [PMC free article] [PubMed]
Allen JD, Robbins JL, Vanbruggen MD, Credeur DP, Johannsen NM, Earnest CP, Pieper CF, Johnson JL, Church TS, Ravussin E, Kraus WE, Welsch MA. Unlocking the barriers to improved functional capacity in the elderly: rationale and design for the “Fit for Life trial”. Contemp Clin Trials. 2013 Sep;36(1):266-75. [PMC free article] [PubMed]
Bowling CB, Booth JN 3rd, Safford MM, Whitson HE, Ritchie CS, Wadley VG, Cushman M, Howard VJ, Allman RM, Muntner P. Nondisease-specific problems and all-cause mortality in the REasons for Geographic and Racial Differences in Stroke (REGARDS) study. J Am Geriatr Soc 2013 May;61(5):739-746. Minority Research Publication [PMC free article] [PubMed]
Chaudry SI, McAvay G, Chen, S, Whitson HE, Newman A, Krumholz HM, Gill T. Risk Factors for Hospital Admission Among Older Persons with Newly Diagnosed Heart Failure: Findings from the Cardiovascular Health Study. J Am Coll Cardiol 2013 Feb 12;61(6):635-642. [PMC free article] [PubMed]
Chou CH, Lee CH, Lu LS, Song IW, Chuang HP, Kuo SY, Wu JY, Chen YT, Kraus VB, Wu CC, Lee MT. Direct assessment of articular cartilage and underlying subchondral bone reveals a progressive gene expression change in human osteoarthritic knees. Osteoarthritis Cartilage. 2013 Mar;21(3):450-61. [PMC free article] [PubMed]
Chou CH, Wu CC, Song IW, Chuang HP, Lu LS, Chang JH, Kuo SY, Lee CH, Wu JY, Chen YT, Kraus VB, Lee MT. Genome-wide expression profiles of subchondral bone in osteoarthritis. Arthritis Res Ther. 2013;15(6):R190. [PMC free article] [PubMed]
Cibere J, Sayre EC, Esdaile JM, Thorne A, Kopec JA, Singer J, Nicolaou S, Garnero P, Poole AR, Kraus VB, Saxne T, Wong H, Guermazi A. Associations of clinical and biomarker variables with cartilage damage in painful pre-radiographic knee osteoarthritis. Results from a population-based study. Osteoarthritis and Cartilage 2013;21(1):S161. [Abstract]
Dolfi DV, Mansfield KD, Kurupati RK, Kannan S, Doyle SA, Ertl HC, Schmader KE, Wherry EJ. Vaccine-induced boosting of influenza virus-specific CD4 T cells in younger and aged humans. PLoS One. 2013;8(10):e77164. [PMC free article] [PubMed]
Dmitrieva NO, Almeida DM, Dmitrieva J, Loken E, Pieper CF. A day-centered approach to modeling cortisol: diurnal cortisol profiles and their associations among US adults. Psychoneuroendocrinology. 2013 Oct;38(10):2354-65. [PMC free article] [PubMed]
Fillenbaum GG, Blay SL, Pieper CF, King KE, Andreoli SB, Gastal FL. The association of health and income in the elderly: experience from a southern state of Brazil. PLoS ONE, 2013, 8(9), e739130. [PMC free article] [PubMed]
Ghazi A, Landerman L, Lien L, Colón-Emeric C. Impact of Race on the Incidence of Hypoglycemia in Hospitalized Older Adults with Type 2 Diabetes Mellitus. Clinical Diabetes 2013;31(2):66. Minority Research Publication [Abstract]
Hall KS, Howe CA, Rana SR, Martin CL, Morey MC. METs and accelerometry of walking in older adults: standard versus measured energy cost. Med Sci Sports Exerc. 2013 Mar;45(3):574-82. PMCID:5822436
Hunter DJ, Eckstein F, Kraus VB, Losina E, Sandell L, Guermazi A. Imaging biomarker validation and qualification report: sixth OARSI Workshop on Imaging in Osteoarthritis combined with third OA Biomarkers Workshop. Osteoarthritis Cartilage. 2013 Jul;21(7):939-42. [PMC free article] [PubMed]
Kraus VB, Worrell TW, Renner JB, Coleman RE, Pieper CF. High prevalence of contralateral ankle abnormalities in association with knee osteoarthritis and malalignment. Osteoarthritis Cartilage. 2013 Nov;21(11):1693-9. [PMC free article] [PubMed]
Kuchibhatla, M.N., Fillenbaum, G.G., Kraus, W.E., Cohen, H.J., & Blazer, D.G. Trajectory classes of body mass index in a representative elderly community sample. J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):699-704. Minority Research Publication [PMC free article] [PubMed]
Levin MJ, Schmader KE, Gnann JW, McNeil SA, Vesikari T, Betts RF, Keay S, Stek JE, Bundick ND, Su SC, Zhao Y, Li X, Chan IS, Annunziato PW, Parrino J. Varicella-zoster virus-specific antibody responses in 50-59-year-old recipients of zoster vaccine. J Infect Dis. 2013 Nov 1;208(9):1386-90. [PMC free article] [PubMed]
Nelson AE, Golightly YM, Renner JB, Schwartz TA, Kraus VB, Helmick CG, Jordan JM. Brief report: Differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: the Johnston County Osteoarthritis Project. Arthritis Rheum. 2013 Feb;65(2):373-7. Minority Research Publication [PMC free article] [PubMed]
Nolan D, Kraus WE, Hauser E, Li YJ, Thompson DK, Johnson J, Chen HC, Nelson S, Haynes C, Gregory SG, Kraus VB, Shah SH. Genome-wide linkage analysis of cardiovascular disease biomarkers in a large, multigenerational family. PLoS One. 2013;8(8):e71779. [PMC free article] [PubMed]
Povsic TJ, Sloane R, Zhou J, Pieper CF, Pearson MP, Peterson ED, Green JB, Cohen HJ, Morey MC. Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial. J Gerontol A Biol Sci Med Sci. 2013 Dec;68(12):1559-66. [PMC free article] [PubMed]
Povsic TJ, Sloane R, Green JB, Zhou J, Pieper CF, Pearson MP, Peterson ED, Cohen HJ, Morey MC. Depletion of circulating progenitor cells precedes overt diabetes: a substudy from the VA enhanced fitness trial. J Diabetes Complications. 2013 Nov-Dec;27(6):633-6. [PMC free article] [PubMed]
Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, Lyle BJ, Martini MC, Ursell LK, Clemente JC, Van Treuren W, Walters WA, Knight R, Newgard CB, Heath AC, Gordon JI. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science. 2013 Sep 6;341(6150):1241214. [PMC free article] [PubMed]
Whitson HE, Whitaker D, Potter G, McConnell E, Tripp F, Sanders LL, Muir KW, Cohen HJ, Cousins SW. A low-vision rehabilitation program for patients with mild cognitive deficits. JAMA Ophthalmol. 2013 Jul;131(7):912-9. [PMC free article] [PubMed]
Wolfe F, Bolster MB, O’Connor CM, Michaud K, Lyles KW, Colón-Emeric CS. Bisphosphonate use is associated with reduced risk of myocardial infarction in patients with rheumatoid arthritis. J Bone Miner Res. 2013 May;28(5):984-91. [PMC free article] [PubMed]
Wu JM, Ward RM, Allen-Brady KL, Edwards TL, Norton PA, Hartmann KE, Hauser ER, Velez Edwards DR. Phenotyping clinical disorders: lessons learned from pelvic organ prolapse. Am J Obstet Gynecol. 2013 May;208(5):360-5. [PMC free article] [PubMed]
Zeng Y, Cheng L, Zhao L, Tan Q, Feng Q, Chen H, Shen K, Li J, Zhang F, Cao H, Gregory SG, Yang Z, Gu J, Tao W, Tian XL, Hauser ER. Interactions between social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China. BMC Geriatr. 2013 Sep 9;13:91. [PMC free article] [PubMed]
Blay SL, Fillenbaum GG, Andreoli SB, Gastal FL. Prevalence and Concomitants of Arthritis in the Elderly in Rio Grande Do Sul, Brazil. PLoS ONE 2012;7(9):e45418. Minority Research Publication [PMC free article] [PubMed]
Catterall JB, Hsueh MF, Stabler TV, McCudden CR, Bolognesi M, Zura R, Jordan JM, Renner JB, Feng S, Kraus VB. Protein Modification by Deamidation Indicates Variations in Joint Extracellular Matrix Turnover. J Biol Chem 2012 Feb 10;287(7):4640-4651. [PMC free article] [PubMed]
Chumbler NR, Quigley P, Li X, Morey M, Rose D, Sanford J, Griffiths P, Hoenig H. Effects of Telerehabilitation on Physical Function and Disability for Stroke Patients: A Randomized, Controlled Trial. Stroke 2012 Aug;43(8):2168-2174. [PubMed]
Cohen RR, Lagoo-Deenadayalan SA, Heflin MT, Sloane R, Eisen I, Thacker JM, Whitson HE. Exploring predictors of complication in older surgical patients: a deficit accumulation index and the Braden scale. J Am Geriat Soc 2012 Sep;60(9):1609-1615. [PMC free article] [PubMed]
Colon-Emeric C, Lee R, Barnard K, Pearson M, Lyles KW. Use of Regional Clinical Data to Identify Veterans for a Multi-Center Osteoporosis Electronic Consult Quality Improvement Intervention. Journal of Hospital Administration 2013 Nov;2(1):8-14. [PDF download link]
Genao L, Whitson HE, Zaas D, Sanders L, Schmader K. Functional Status after Lung Transplantation in Older Adults in the Post-Allocation Score Era. Am J Transplant 2013 Jan;13(1):157-166. [PMC free article] [PubMed]
Goode AP, Marshall SW, Renner JB, Carey TS, Kraus VB, Irwin DE, Sturmer T, Jordan JM. Lumbar Spine Radiographic Features and Demographic, Clinical, and Radiographic Knee, Hip and Hand Osteoarthritis. Arthritis Care Res (Hoboken) 2012 Oct;64(10):1536-1544. [PMC free article] [PubMed]
Hoenig H, Landerman LR, Shipp KM, Richardson M, Pieper C, Hubbard-Winkler S. A Preliminary Predictive Model for Wheelchair Use 4 Month after Receipt. Technology and Disability 2012;24(1):71-81. [Abstract]
Huebner JL, Landerman LR, Somers TJ, Kraus VB, Guilak F, Blumenthal JA, Caldwell DS, Rice JR, Keefe FJ. Inflammatory Biomarkers of Oa, Il-6 and Leptin Are Modifiable in Overweight/Obese Oa Patients with a Protocol That Combines Training in Pain Coping Skills and Weight Management. Osteoarthritis and Cartilage 2012;20(1):S38. [Abstract]
Huffman KM, Redman LM, Landerman LR, Pieper CF, Stevens RD, Muehbauer MJ, Wenner BR, Bain JR, Kraus VB, Newgard CB, Ravussin E, Kraus WE. Caloric Restriction Alters the Metabolic Response to a Mixed-Meal: Results from a Randomized, Controlled Trial. PLoS ONE 2012;7(4):e28190. [PMC free article] [PubMed]
Kuchibhatla MN, Fillenbaum GG, Hybels CF, Blazer DG. Trajectory classes of depressive symptoms in a community sample of older adults. Acta Psychiatr Scand 2012 Jun;125(6)492-501. Minority Research Publication [PMC free article] [PubMed]
Lee R, Colón-Emeric C. Effectiveness of osteoporosis therapy among frail, older adults: Should we carry out more trials? Aging Health 2012 (Oct);8(5):461-470. [Journal Issue link]
Miller PE, Morey MC, Hartman TJ, Snyder DC, Sloane R, Cohen HJ, Demark-Wahnefried W. Dietary Patterns Differ between Urban and Rural Older, Long-Term Survivors of Breast, Prostate, and Colorectal Cancer and Are Associated with Body Mass Index. J Acad Nutr Diet 2012;112(6):824-831. [PMC free article] [PubMed]
Morey MC, Pieper CF, Edelman DE, Yancy WS Jr, Green JB, Lum H, Peterson MJ, Sloane R, Cowper PA, Bosworth HB, Huffman KM, Cavanaugh JT, Hall KS, Pearson MP, Taylor GA. Enhanced Fitness: A Randomized Controlled Trial of the Effects of Home-Based Physical Activity Counseling on Glycemic Control in Older Adults with Prediabetes Mellitus. J Am Geriatr Soc 2012 Sep;60(9):1655-1662. [PMC free article] [PubMed]
Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, Debalsi KL, Ilkayeva OR, Stevens RD, Kheterpal I, Zhang J, Covington JD, Baipeyi S, Ravussin E, Kraus W, Koves TR, Mynatt RL. Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility. Cell Metab 2012 May;15(5):764-777. [PMC free article] [PubMed]
Nipp R, Sloane R, Rao AV, Schmader KE, Cohen HJ. Role of Pain Medications, Consultants, and Other Services in Improved Pain Control of Elderly Adults with Cancer in Geriatric Evaluation and Management Units. J Am Geriatr Soc 2012 Oct;60(10):1912-1917. [PMC free article] [PubMed]
Purser JL, Feng Q, Yi Z, Hoenig H. A New Classification of Function and Disability in China: Subtypes Based on Performance-Based and Self-Reported Measures. J Aging Health 2012 Aug;24(5):779-798. [PMC free article] [PubMed]
Purser JL, Golightly YM, Feng Q, Helmick CG, Renner JB, Jordan JM. Association of Slower Walking Speed with Incident Knee Osteoarthritis-Related Outcomes. Arthritis Care Res 2012 Jul;64(7):1028-1035. [PMC free article] [PubMed]
Sun AY, Nilsson KR, Jr. Early Repolarization: A Sword in the Haystack? Heart Rhythm 2012 Aug;9(8):1301-1302. [PubMed]
Thielke S, Whitson HE, Diehr P, O’Hare A, Kearney P, Chaudhry S, Zakai N, Kim D, Sekaran N, Sale J, Arnold A, Chaves P, Newman AB. Persistence and remission of musculoskeletal pain in community-dwelling older adults: results from the Cardiovascular Health Study. J Am Geriatr Soc 2012 Aug;60(8):1393-1400. [PMC free article] [PubMed]
Toles M, Barroso J, Colón-Emeric CS, Corazzini K, McConnell E, Anderson R. Staff Interaction Strageties that Optomize deliver of Transitional Care in a Skilled Nursing Facility: A Multiple-Case Study. Fam Community Health 2012 Oct-Dec;35(4):334-344. [PMC free article] [PubMed]
Whitson HE, Malhotra R, Chan A, Matchar DB, Ostbye T. Comorbid Visual and Cognitive Impairment: Relationship with Disability Status and Self-Rated Health among Older Singaporeans. Asia Pac J Public Health 2014 May;26(3):310-319. [PMC free article] [PubMed]
Whitson HE, Whitaker D, Sanders LL, Potter GG, Cousins SW, Ansah D, McConnell E, Pieper CF, Landerman L, Steffens DC, Cohen HJ. Memory deficit associated with worse functional trajectories in older adults in low vision rehabilitation for macular disease. J Am Geriatr Soc 2012 Nov;60(11):2087-2092. [PMC free article] [PubMed]
Wolfe F, Bolster M, O’Connor C, Michaud K, Lyles KW, Colón-Emeric CS. Bisphosphonate use is associated with reduced risk of myocardial infarction in patients with rheumatoid arthritis. J Bone Miner Res 2012 May;28(5):984-991. [PMC free article] [PubMed]
Yin ZX, Shi XM, Kraus VB, Fitzgerald SM, Qian HZ, Xu JW, Zhai Y, Sereny MD, Zeng Y. High Normal Plasma Triglycerides Are Associated with Preserved Cognitive Function in Chinese Oldest-Old. Age Ageing 2012 Sep;41(5):600-606. [PMC free article] [PubMed]
Blay SL, Fillenbaum GG, Marinho V, Andreoli SB, Gastal FL. Increased health burden associated with comorbid depression in older Brazilians with diabetes. J Affect Disord 2011 Nov;134(1-3):77-84. [PMC free article] [PubMed]
Brummett BH, Babyak MA, Grønbæk M, Barefoot JC. Positive emotion is associated with 6-year change in functional status in individuals aged 60 and older. The Journal of Positive Psychology 2011 Sept;6(3):216-223. [Abstract]
Cheng AWM, Stabler TV, Bolognesi M, Kraus VB. Selenomethionine inhibits IL-1β inducible nitric xxide synthase (iNOS) and cyclooxygenase 2 (Cox2) expression in primary human chondrocytes. Osteoarthritis Cartilage 2011 Jan;19(1):118-125. [PMC free article] [PubMed]
Christy SM, Mosher CE, Sloane R, Snyder DC, Lobach DF, Demark-Wahnefried W. Long-term dietary outcomes of the FRESH START intervention for breast and prostate cancer survivors. J Am Diet Assoc 2011 Dec;111(12):1844-1851. [PMC free article] [PubMed]
Denoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, McDaniel GE, Coleman RE, Kraus VR. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proc Natl Acad Sci U S A. Feb 1 2011;108(5):2088-2093. [PMC free article] [PubMed]
Feng Q, Purser JL, Zhen Z, Duncan PW. Less exercise and more TV: leisure-time physical activity trends of shanghai elders, 1998-2008. J Public Health (Oxf). 2011 Dec;33(4):543-550. [PubMed]
Golightly YM, Marshall SW, Kraus VB, Renner JB, Villaveces A, Casteel C, Jordan JM. Biomarkers of incident radiographic knee osteoarthritis: Do they vary by chronic knee symptoms? Arthritis Rheum 2011 Aug;63(8):2276-2283. [PMC free article] [PubMed]
Hall K, Pieper C, Edelman D, Yancy WS Jr, Green JB, Lum H, Peterson MJ, Sloane R, Cowper PA, Bosworth HB, Huffman KM, Cavanaugh JT, Chapman JG, Pearson MP, Howard TA, Ekelund CC, McCraw BL, Burrell JB, Taylor GA, Morey MC. Lessons learned when innovations go awry: A baseline description of a behavioral trial-the enhancing fitness in older overweight veterans with impaired fasting glucose study. Transl Behav Med 2011 Nov;1(4):573-587. [PMC free article] [PubMed]
Hayden KM, Jones RN, Zimmer C, Plassman BL, Browndyke JN, Pieper C, Warren LH, Welsh-Bohmer KA. Factor structure of the National Alzheimer’s Coordinating Centers uniform dataset neuropsychological battery: An evaluation of invariance between and within groups over time. Alzheimer Dis Assoc Disord 2011 Apr-Jun;25(2):128-137. [PMC free article] [PubMed]
Huffman KM, Pieper CF, Kraus VB, Kraus WE, Fillenbaum GG, Cohen HJ. relations of a marker of endothelial activation (s-VCAM) to function and mortality in community-dwelling older adults. J Gerontol A Biol Sci Med Sci 2011 Dec;66(12):1369-1375. [PMC free article] [PubMed]
Huffman KM, Slentz CA, Bateman LA, Thompson D, Muehlbauer MJ, Bain JR, Stevens RD, Wenner BR, Kraus VB, Newgard CB, Kraus WE. Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity. Diabetes Care 2011 Jan;34(1):174-176. [PMC free article] [PubMed]
Hybels CF, Blazer DG, Landerman LR, Steffens DC. Heterogeneity in symptom profiles among older adults diagnosed with major depression. Int Psychogeriatr 2011 Aug;23(6):906-922. [PMC free article] [PubMed]
Jones LW, Eves ND, Spasojevic I, Wang F, Il’yasova D. Effects of aerobic training on oxidative status in postsurgical non-small cell lung cancer patients: A pilot study. Lung Cancer 2011 Apr;72(1):45-51. [PMC free article] [PubMed]
Kenjale AA, Ham KL, Stabler T, Robbins JL, Johnson JL, Vanbruggen M, Privette G, Yim E, Kraus WE, Allen JD. Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol 2011 Jun;110(6):1582-1591. [PMC free article] [PubMed]
Kuchibhatla MN, Fillenbaum GG. Trajectory classes of depression in a randomized depression trial of heart failure patients: A reanalysis of the SADHART-CHF trial. Am J Geriatr Pharmacother 2011 Dec;9(6):483-494. [PMC free article] [PubMed]
Landerman LR, Mustillo SA, Land KC. Modeling repeated measures of dichotomous data: Testing whether the within-person trajectory of change varies across levels of between-person factors. Soc Sci Res 2011 Sep 1;40(5):1456-1464. [PMC free article] [PubMed]
Lum H, Sloane R, Huffman KM, Kraus VB, Thompson DK, Kraus WE, Bain JR, Stevens R, Pieper CF, Taylor GA, Newgard CB, Cohen HJ, Morey MC. Plasma Acylcarnitines Are Associated with Physical Performance in Elderly Men. J Gerontol A Biol Sci Med Sci 2011 May;66(5):548-553. [PMC free article] [PubMed]
Nelson, AE, Chaudhary, S, Kraus, VB, Fang, F, Chen, J-C, Schwartz, TA, Shi, XA, Renner, JB, Stabler, TV, Helmick, CG, Caldwell, K, Poole, AR, Jordan, JM. Whole blood lead levels are associated with biomarkers of joint tissue metabolism in African American and white men and women: The Johnston County Osteoarthritis Project. Environ Res. 2011 Nov;111(8): 1208-1214. Minority Research Publication [PMC free article] [PubMed]
Nelson, AE, Renner, JB, Schwartz, TA, Kraus, VB, Helmick, CG, Jordan, JM. Differences in multijoint radiographic osteoarthritis phenotypes among African Americans and Caucasians: The Johnston County Osteoarthritis project. Arthritis Rheum. 2011 Dec;63(12):3843-3852. Minority Research Publication [PMC free article] [PubMed]
Ostbye T, Malhotra R, Landerman LR. Body mass trajectories through adulthood: Results from the National Longitudinal Survey of Youth 1979 Cohort (1981-2006). Int J Epidemiol 2011 Feb;40(1):240-250. [PubMed]
Pieper C, Redman L, Racette S, Roberts S, Bhapkar M, Rochon J, Martin C, Kraus W, Das S, Williamson D, Ravussin E. Development of adherence metrics for caloric restriction interventions. Clin Trials. 2011 Apr;8(2):155-164. [PMC free article] [PubMed]
Redman LM, Huffman KM, Landerman LR, Pieper CF, Bain JR, Muehlbauer MJ, Stevens RD, Wenner BR, Kraus VB, Newgard CB, Kraus WE, Ravussin E. Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women. J Clin Endocrinol Metab. 2011 Feb;96(2):E312-321. [PMC free article] [PubMed]
Sun AY, Koontz JI, Shah SH, Piccini JP, Nilsson KR Jr, Craig D, Haynes C, Gregory SG, Hranitzky PM, Pitt GS. The S1103Y cardiac sodium channel variant is associated with implantable cardioverter-defibrillator events in blacks with heart failure and reduced ejection fraction. Circ Cardiovasc Genet 2011 Apr;4(2):163-168. [PMC free article] [PubMed]
Whitson HE, Hastings SN, Landerman LR, Fillenbaum GG, Cohen HJ, Johnson KS. Black-White disparity in disability: The role of medical conditions. J Am Geriatr Soc 2011 May;59(5):844-850. Minority Research Publication [PMC free article] [PubMed]
Whitson HE, Steinhauser K, Ammarell N, Whitaker D, Cousins SW, Ansah D, Sanders LL, Cohen HJ. Categorizing the effect of comorbidity: A qualitative study of individuals’ experiences in a low-vision rehabilitation program. J Am Geriatr Soc 2011 Oct;59(10):1802-1809. [PMC free article] [PubMed]
Whitson HE, Thielke S, Diehr P, O’Hare AM, Chaves PH, Zakai NA, Arnold A, Chaudhry S, Ives D, Newman AB. Patterns and predictors of recovery from exhaustion in older adults: The cardiovascular health study. J Am Geriatr Soc 2011 Feb;59(2):207-213. [PMC free article] [PubMed]
Brummett BH, Boyle SH, Kuhn CM, Siegler IC, Williams RB. Socioeconomic status moderates associations between CNS serotonin and expression of beta2-integrins CD11b and CD11c. J Psychiatr Res 2010 Apr;44(6):373-377. [PMC free article] [PubMed]
Cavanaugh JT, Kochi N, Stergiou N. Nonlinear Analysis of Ambulatory Activity Patterns in Community-Dwelling Older Adults. J Gerontol A Bio Sci Med Sci 2010 Feb;65(2):197-203. [PMC free article] [PubMed]
Chen HC, Kraus VB, Li YJ, Nelson S, Haynes C, Johnson J, Stabler T, Hauser E, Gregory G, Kraus WE, Shah S. Genome-wide linkage analysis of quantitative biomarker traits of osteoarthritis in a large multigenerational extended family. Arthritis Rheum. 2010 Mar;62(3):781-790. Minority Research Publication [PMC free article] [PubMed]
Chen TD, Anderson DJ, Chopra T, Choi Y, Schmader KE, Kaye KS. Poor Functional Status is an Independent Predictor of Surgical Site Infections due to Methicillin-Resistant Staphylococcus aureus in Older Adults. J Am Geriatric Soc 2010 Mar;58(3):527-532. [PMC free article] [PubMed]
Fillenbaum GG, Blay SL, Andreoli SB. Prevalence and Correlates of Functional Status in an Older Community-Representative Sample in Brazil. J Aging Health 2010 Apr;22(3):362-383. [PMC free article] [PubMed]
Fillenbaum GG, Kuchibhatla MN, Whitson HE, Batch BC,Svetkey LP, Pieper CF, Kraus WE, Cohen HJ, Blazer DG. Accuracy of self-reported height and weight in a community-based sample of older African Americans and Whites. J Gerontol A Biol Sci Med Sci 2010 Oct;65(10):1123-1129. Minority Research Publication [PMC free article] [PubMed]
Hall KSM, Crowley GM, McConnell ES, Bosworth HB, Sloane RS, Ekelund CC, Morey MC. Change in goal ratings as a mediating variable between self-efficacy and physical activity in older men. Ann of Behav Med 2010 Jun;39(3):267-273. [PMC free article] [PubMed]
Huffman KM, Hall KS, Sloane R, Peterson MJ, Bosworth HB, Ekelund CC, Pearson MP, Howard T, Pieper CF, Morey MC. Is Diabetes Associated with poorer self-efficacy and motivation for physical activity in older adults with arthritis? Scand J Rheumatol 2010;39(5):380-386. [PMC free article] [PubMed]
Huffman KM, Sloane R, Peterson MJ, Bosworth HB, Ekelund CC, Pearson MP, Howard T, Pieper CF, Morey MC. The impact of self-reported arthritis and diabetes on response to a home-based physical activity counseling intervention. Scan J Rheumatol 2010 May;39(3):233-239. [PMC free article] [PubMed]
Hybels CF, Pieper CF, Blazer DG, Fillenbaum GG, Steffens DC. Trajectories of mobility and IADL function in older patients diagnosed with major depression. Int J Geriatri Psychiatry 2010 Jan;25(1):74-81. [PMC free article] [PubMed]
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Fillenbaum GG, Hybels CF, Pieper CF, Konrad TR, Burchett BM, Blazer DG. Provider characteristics related to antidepressant use in the elderly. J Am Geriatr Soc 2006, 54:942-949. Minority Research Publication [PDF link] [PubMed]
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Purser JL, Fillenbaum GG, Wallace RB. Memory Complaint Is Not Necessary for Diagnosis of Mild Cognitive Impairment and Does Not Predict 10-year Trajectories of Functional Disability, Word Recall or Short Portable Mental Status Questionnaire Limitations. J Am Geriatr Soc 2006 Feb;54(2):335-338. [PubMed]
Purser JL, Kuchibhatla MN, Fillenbaum GG, Harding T, Peterson ED, Alexander KP. Identifying Frailty Among Hospitalized Older Adults with Significant Coronary Artery Disease. J Am Geriatr Soc 2006 Nov;54(11):1674-1681. [PubMed]
Rao AV, Demark-Wahnefried W. The older cancer survivor. Crit Rev Oncol Hematol 2006 Nov;60(2):131-143. [PubMed]
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Purser,JL, Fillenbaum, GG, Pieper, CF, Wallace, RB. Mild Cognitive Impairment and 10-Year Trajectories of Disability in the Iowa Established Populations for Epidemiologic Studies of the Elderly Cohort. J Am Geriatr Soc 2005 Nov;53(11):1966-1972. [PubMed]
Purser JL, Weinberger M, Cohen HJ, Pieper CF, Morey MC, Li T, Williams GR, Lapuerta P. Walking speed predicts health status and hospital costs for frail elderly veterans. J Rehab Res Dev 2005 Jul-Aug;42(4):535-546. [PubMed]
Schildkraut JM, Demark-Wahnefried W, Wenham RM, Grubber J, Jeffreys A, Grambow S, Marks J, Moorman PG, Hoyo C, Ali S, Walther PJ. IGF1 (CA)19 Repeat and IGFBP3 -202 A/C Genotypes and the Risk of prostate Cancer in Black and White Men. Cancer Epidemiol Biomarkers Prev 2005 Feb;14(2):403-308. Minority Research Publication [PubMed]
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Blumenthal JA, Emery CF, Madden DJ, Schniebolk S, Riddle MW, Cobb FR, Higginbotham MB, Coleman RE. Effects of exercise training on bone density in older men and women. J Am Geriatr Soc 1991 Nov;39(11):1065-1070. [PubMed]
Kitzman D, Sheikh K, Beere P, Philips J, Higginbotham,M. Age-related alterations of doppler left ventricular filling indexes in normal subjects are independent of left ventricular mass, heart rate, contractility and loading conditions. J Am Coll Cardiol 1991 Nov;18(5):1243-1250. [PubMed]
Krucoff MW, Higginbotham MB, Van Trigt P, Sawchak ST, Jones RH, Wall TC, Phillips HR, Stack RS, Reeves JG. From HIRMIT to the Cape May Lighthouse. Revascularization reconsidered in very high risk patients at the Duke Heart Center. N.C. Med J 1991 Dec;52(12):618-620. [PubMed]
Weiner DK, Allen NB. Large vessel vasculitis of the central nervous system in systemic lupus erythematosus: Report and review of the literature. J Rheumatol 1991 May;18(5):748-751. [PubMed]
The CARiNG-StARR (Creating Alzheimer’s Disease and Related Dementias Researchers for the Next Generation – Stimulating Access to Research in Residency) Pathway supports protected time for residents to conduct research on issues related to Alzheimer’s disease and related dementias (ADRD). The program’s goal is to help residents develop into independent physician-scientists who use cutting-edge research methods to pursue long-term academic careers investigating ADRD issues. These opportunities are supported by an active R38 StARR award to Duke University School of Medicine from NIA.
All residents in the CARiNG-StARR program will have a primary research mentor in laboratory-based basic science research, clinical research, or health services research focusing on ADRD. In addition, a Scholarship Oversight Committee (SOC) will meet with each resident in the program at least twice per year and help the trainee create an individualized development plan.
Benefits of the Program
- Selected residents appointed to the CARiNG-StARR Research Residency Pathway will establish a record of accomplishment of scholarly activities. This includes:
- Application submission for an external individual career development award (National Research Service Award (NRSA) Individual Postdoctoral Fellowship or K38) Stimulating Access to Research in Residency Transition Scholar (StARRTs)
- Participation in scientific meetings
- Submission of research manuscripts to peer-reviewed journals
- 12 months of protected time for research integrated with clinical training
- Enhanced physician-scientist career mentorship opportunities from the primary research mentor, the Scholarship Oversight Committee, and the CARiNG-StARR program directors
- An opportunity to apply for a technician or research assistant to maintain research productivity during blocks of clinical residency training
- Strengthened candidacy for Duke University School of Medicine subspecialty fellowship programs
- Funds to support conference travel and research needs
- Eligibility to apply for a new NIH early career award (K38 StARRTs)
- Eligibility to apply for shortened subspecialty fellowship training time, based on approval by their specialty board
Duke University School of Medicine interns and PGY2 residents in good clinical standing are eligible to apply to the program.
Priority is given to residents from the departments of Family Medicine & Community Health, Neurology, and Psychiatry & Behavioral Sciences.
Please see department websites for details specific to their trainees:
- Department of Family Medicine & Community Health
- Department of Neurology
- Department of Psychiatry & Behavioral Sciences
- A one-page personal statement describing the applicant’s intended scientific career trajectory
- An NIH-style biosketch
- A one- to two-page scientific proposal, formatted as an NIH-style specific aims page, describing a core research project to be completed during the training period
- A letter of support from a Duke faculty member who has agreed to serve as the applicant’s research mentor
Deadline to apply is November 30.
Completed applications should be sent to Ashley Price, PhD, MPH, CARiNG StARR coordinator. Applicants will receive an email confirming receipt.
Potential applicants are encouraged to meet with their department residency and R38 program representatives to express interest.
The Research Education Component (REC) recognizes that training in aging research faces several unique challenges, including difficulties recruiting geriatricians into research careers and a lack of training in the principles of aging research by other medical disciplines.
The objective of the Research Education Component will be to develop the next generation of researchers who will become leaders in integrating basic science and clinical insights into innovative interventions promoting reserve and resilience in late life.
Cathleen Colón-Emeric, MD, MHS
Professor of Medicine
Chief, Division of Geriatrics
Associate Director-Clinical at the Durham VA Geriatrics Research Education and Clinical Center (GRECC), Adjunct Faculty at the Duke School of Nursing and Duke Clinical Research Institute
Current research focuses on the epidemiology, prediction, and prevention of osteoporotic fractures in elderly persons, and in improving the quality of care delivered to residents in skilled nursing facilities. Ongoing projects include a large, administrative database study of osteoporosis screening in men, a randomized trial of different staff education strategies to improve fall prevention in nursing homes, and several clinical demonstration projects. In 2017, Dr Colón-Emeric received the Clinical Sciences Research Mentoring Award from the Department of Medicine, and in 2018 she was appointed Associate Dean for Research Mentoring for the School of Medicine.
Kimberly Johnson, MD
Associate Professor of Medicine
Associate Director of the CTSA KL-2 program
Dr Johnson leads the Duke Center for REsearch to AdvanCe Healthcare Equity (REACH), where researchers study the effect of a clinician communication coaching intervention—teaching empathic skills and eliciting participatory behaviors—on the quality of communication in cardiology encounters with African American patients; test the use of a mobile app for African American patients receiving palliative care in the ICU and their families to self-report needs, obtain information about patient/family needs, and access decisional support; and develop and pilot test an implicit bias training intervention for providers.
2020 PEPPER CAREER DEVELOPMENT AWARDS
Brian Andonian, MD (Division of Rheumatology and Immunology/Dept. of Medicine)
Accelerated metabolic aging in rheumatoid arthritis immune cells and skeletal muscle: A pilot study
- Rheumatoid arthritis (RA) is a model disease for studying premature aging. Persons with RA suffer from
early aging-associated metabolic comorbidities, and are at risk for low resilience, a decreased ability to resist
functional decline. Mitochondrial function in RA and aging is a marker of cellular reserve, and is thus important for preserving resilience. RA and aged immune cells have abnormal mitochondrial function, which coincide with immune dysregulation. Skeletal muscle in both RA and aging is also marked by altered mitochondria. The pilot study will investigate whether dysfunction of mitochondria, the cellular metabolic “engine,” connects RA peripheral helper T-cells, macrophages and skeletal muscle abnormalities. Objectives are twofold:
1) to determine whether RA T cell, macrophage and skeletal muscle mitochondrial function abnormalities are associated, and
2) to determine associations of exercise training on RA immune cell and skeletal muscle mitochondria.
- Rheumatoid arthritis (RA) is a model disease for studying premature aging. Persons with RA suffer from
Ming-Feng Hsueh, PhD (Dept. of Orthopedic Surgery)
Harness human cartilage repair capability to prevent and reverse osteoarthritis
- Humans have a natural cartilage repair response which is high in the ankle, intermediate in the knee and low in hip cartilages. This repair response in humans is highly associated with the microRNAs used by salamanders and other limb regenerating animals to regenerate whole limbs. This project will evaluate the ability of microRNAs as a therapy to improve cartilage resilience to injury in vitro, and build the foundation for further evaluation in animals for microRNAs’ ability to prevent and reverse the most prevalent of age-related diseases, osteoarthritis, for which we currently have no disease-modifying treatments.
Daniel C. Parker, MD (Division of Geriatrics/Dept. of Medicine)
Identification of biomarkers of cognitive resilience in the Duke Performance Across the LifeSpan (PALS) Study
- Cognitive resilience is defined as preserved cognitive function in the setting of “stressors” that adversely
affect cognitive function; it may explain – in part – the heterogeneity of cognitive function in older adults who
otherwise appear clinically similar, especially with respect to risk factors for Alzheimer’s disease and related
dementias (ADRD). Blood-based biomarkers of cognitive resilience would be useful to identify protective factors and test resilience-building interventions that preserve cognitive function in the setting of these stressors; currently, no such biomarkers exist. Building on previous work, I propose to develop a measure of cognitive resilience in a subset of community-dwelling older adults from the Duke Performance Across the LifeSpan (PALS; N=297) study with repeat cognitive testing over 3 years. Using this measure, I will identify biomarkers reflecting dysregulation in “Hallmarks of Aging” pathways that are predictive of cognitive resilience.
- Cognitive resilience is defined as preserved cognitive function in the setting of “stressors” that adversely
2018 PEPPER CAREER DEVELOPMENT AWARDS
Nazema Siddiqui, MD (Dept. of Obstetrics and Gynecology)
Effects of aging and the urinary microbiome on recurrent urinary tract infections
- Specific interests include: 1) pathophysiology of overactive bladder with particular emphasis on epigenetic mechanisms; and 2) studying the urinary microbiome with aging and in women with recurrent urinary tract infection. Additional interests include clinical outcomes research after surgery for prolapse and other pelvic floor disorders.
Corey Simon, DPT, PhD (Dept. of Orthopedic Surgery)
Physical Resilience to Pain with Activity Influences among Seniors (PRAISE) – Feasibility Study
- Research focuses on development of tailored multi-factorial interventions that prevent disability among older adults with low back pain. Low back pain poses a major risk to senior health, as it is the global leader in years lived with disability and strongly associated with mobility disability. However, it is not clear why some older adults with low back pain succumb to mobility disability while others do not. This REC study will determine the feasibility of assessing three factors that may explain mobility disability among older adults with low back pain: pain with activity, fear of movement, and dynamic inflammatory response to movement.
Tony Sung, MD (Division of Hematologic Malignancies and Cellular Therapy/Dept. of Medicine)
High intensity interval training to improve pre- and peri-transplant function and outcomes
- Research focuses on strategies to reduce complications of HCT and ranges from preclinical studies using murine models of HCT to Phase 1 and Phase 2 clinical trials. Areas of interest include the role of the microbiota (the trillions of bacteria living in and on our bodies), nutrition, and exercise in modulating HCT outcomes such as graft-versus-host disease (GVHD) and infections.
PREVIOUS PEPPER RESEARCH SCHOLARS Since its inception, the Duke Pepper Center has produced an impressive portfolio of relevant research and innovations in faculty development. One of its many accomplishments is support and mentoring of numerous promising investigators whose careers focus on relevant aging related research at Duke. In 2009, in recognition of the contributions of these young investigators, career development and pilot project awardees, the Duke Pepper Center established a Duke Pepper Scholars Program. Previous awardees: Jason Allen, PhD, Cardiology Kelli Allen, PhD, General Internal Medicine Raquel R. Bartz, MD, Anesthesiology Dan Belsky, PhD, Geriatrics Beverly Brummett, MD, Medical Psychology James T. Cavanaugh PT, PhD, Geriatrics Jessica Chia, MD, Pulmonary, Allergy and Critical Care Medicine Jennifer Dungan, RN, PhD, School of Nursing William Michael Foster, PhD, Pulmonary and Critical Care Medicine Farshid Guilak, PhD, Orthopedic Surgery and Cell Biology Katherine Hall, PhD, Geriatrics Rasheeda Hall, MD, Nephrology Susan Nichole Hastings, MD, Geriatrics Matthew Hirschey, PhD, Chemistry and Biochemistry Kim Huffman, MD, Rheumatology and Immunology Kimberly Johnson, MD, Geriatrics Lee Jones, PhD, Radiation Oncology Timothy Koves, PhD, Geriatrics Richard Lee, MD, Endocrinology and Metabolism Helen Lum, MD, Geriatrics David Madden, PhD, Psychiatry and Behaviorial Sciences Micah McClain, MD, Infectious Diseases Mehri McKellar, MD, Infectious Diseases Deborah M. Muoio, PhD, Endocrinology & Metabolomics Kent Nilsson, MD, Cardiology Amy Pastva, PhD, Community and Family Medicine Juliessa Pavon, MD, Geriatrics Matthew Peterson, PhD, Geriatrics Thomas Povsic, MD, Cardiology Jama L. Purser, PT, PhD, Geriatrics Arati Rao, MD, Medicine Gregory Sempowski, PhD, Duke Human Vaccine Institute Svati H. Shah, MD, MHS, Epidemiology, Medical Genomics Heather E. Whitson, MD, Geriatrics RECENT PUBLICATIONS Simon CB, Lentz TA, Orr L, Bishop MD, Fillingim RB, Riley JL 3rd, George SZ. Static and Dynamic Pain Sensitivity in Adults with Persistent Low Back Pain: Comparison to Healthy Controls and Associations with Movement-Evoked Pain Versus Traditional Clinical Pain Measures. Clin J Pain. 2021 Jul 1;37(7):494-503. PMID:33999558 Institutional access PMCID:8194013 Available 7/1/2022 Hsueh MF, Zhang X, Wellman SS, Bolognesi MP, Kraus VB. Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression. Arthritis Rheumatol. 2021 Jan;73(1):89-99. PMCID:7876152 Available 02/11/2022 Bickhaus JA, Vaughan M, Truong T, Li YJ, Siddiqui NY. A comparison of antibiotic prophylaxis regimens to decrease the risk of post-procedure urinary tract infection after onabotulinum toxin A injection. Int Urogynecol J. 2020 Sep;31(9):1907-1912. PMCID:7498079 Parker DC, Bartlett BN, Cohen HJ, Fillenbaum G, Huebner JL, Kraus VB, Pieper C, Belsky DW. Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults. J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):1671-1679. Minority Research Publication PMCID:7494046 Sung AD, Jauhari S, Siamakpour-Reihani S, Rao AV, Staats J, Chan C, Meyer E, Gadi VK, Nixon AB, Lyu J, Xie J, Bohannon L, Li Z, Hourigan CS, Dillon LW, Wong HY, Shelby R, Diehl L, de Castro C, LeBlanc T, Brander D, Erba H, Galal A, Stefanovic A, Chao N, Rizzieri DA. Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects. Am J Hematol. 2020 Jun;95(6):662-671. PMCID:7433709 Hall RK, Cary MP Jr, Washington TR, Colón-Emeric CS. Quality of life in older adults receiving hemodialysis: a qualitative study. Qual Life Res. 2020 Mar;29(3):655-663. PMCID:7028790 Hall RK, Zhou H, Reynolds K, Harrison TN, Bowling CB. A Novel Approach to Developing a Discordance Index for Older Adults With Chronic Kidney Disease. J Gerontol A Biol Sci Med Sci. 2020 Feb 14;75(3):522-528. PMCID:7768728 Pavon JM, Sloane RJ, Pieper CF, Colón-Emeric CS, Cohen HJ, Gallagher D, Hall KS, Morey MC, McCarty M, Hastings SN. Accelerometer-Measured Hospital Physical Activity and Hospital-Acquired Disability in Older Adults. J Am Geriatr Soc. 2020 Feb;68(2):261-265. PMCID:7002200 Johnson KS, Payne R, Kuchibhatla MN. What are Hospice Providers in the Carolinas Doing to Reach African Americans in Their Service Area? J Palliat Med. 2016 Feb;19(2):183-189. Minority Research Publication PMCID:4753631
Since its inception, the Duke Pepper Center has produced an impressive portfolio of relevant research and innovations in faculty development. One of its many accomplishments is support and mentoring of numerous promising investigators whose careers focus on relevant aging related research at Duke. In 2009, in recognition of the contributions of these young investigators, career development and pilot project awardees, the Duke Pepper Center established a Duke Pepper Scholars Program.
Jason Allen, PhD, Cardiology
Kelli Allen, PhD, General Internal Medicine
Raquel R. Bartz, MD, Anesthesiology
Dan Belsky, PhD, Geriatrics
Beverly Brummett, MD, Medical Psychology
James T. Cavanaugh PT, PhD, Geriatrics
Jessica Chia, MD, Pulmonary, Allergy and Critical Care Medicine
Jennifer Dungan, RN, PhD, School of Nursing
William Michael Foster, PhD, Pulmonary and Critical Care Medicine
Farshid Guilak, PhD, Orthopedic Surgery and Cell Biology
Katherine Hall, PhD, Geriatrics
Rasheeda Hall, MD, Nephrology
Susan Nichole Hastings, MD, Geriatrics
Matthew Hirschey, PhD, Chemistry and Biochemistry
Kim Huffman, MD, Rheumatology and Immunology
Kimberly Johnson, MD, Geriatrics
Lee Jones, PhD, Radiation Oncology
Timothy Koves, PhD, Geriatrics
Richard Lee, MD, Endocrinology and Metabolism
Helen Lum, MD, Geriatrics
David Madden, PhD, Psychiatry and Behaviorial Sciences
Micah McClain, MD, Infectious Diseases
Mehri McKellar, MD, Infectious Diseases
Deborah M. Muoio, PhD, Endocrinology & Metabolomics
Kent Nilsson, MD, Cardiology
Amy Pastva, PhD, Community and Family Medicine
Juliessa Pavon, MD, Geriatrics
Matthew Peterson, PhD, Geriatrics
Thomas Povsic, MD, Cardiology
Jama L. Purser, PT, PhD, Geriatrics
Arati Rao, MD, Medicine
Gregory Sempowski, PhD, Duke Human Vaccine Institute
Svati H. Shah, MD, MHS, Epidemiology, Medical Genomics
Heather E. Whitson, MD, Geriatrics
Simon CB, Lentz TA, Orr L, Bishop MD, Fillingim RB, Riley JL 3rd, George SZ. Static and Dynamic Pain Sensitivity in Adults with Persistent Low Back Pain: Comparison to Healthy Controls and Associations with Movement-Evoked Pain Versus Traditional Clinical Pain Measures. Clin J Pain. 2021 Jul 1;37(7):494-503. PMID:33999558 Institutional access PMCID:8194013 Available 7/1/2022
Hsueh MF, Zhang X, Wellman SS, Bolognesi MP, Kraus VB. Synergistic Roles of Macrophages and Neutrophils in Osteoarthritis Progression. Arthritis Rheumatol. 2021 Jan;73(1):89-99. PMCID:7876152 Available 02/11/2022
Bickhaus JA, Vaughan M, Truong T, Li YJ, Siddiqui NY. A comparison of antibiotic prophylaxis regimens to decrease the risk of post-procedure urinary tract infection after onabotulinum toxin A injection. Int Urogynecol J. 2020 Sep;31(9):1907-1912. PMCID:7498079
Parker DC, Bartlett BN, Cohen HJ, Fillenbaum G, Huebner JL, Kraus VB, Pieper C, Belsky DW. Association of Blood Chemistry Quantifications of Biological Aging With Disability and Mortality in Older Adults. J Gerontol A Biol Sci Med Sci. 2020 Sep 16;75(9):1671-1679. Minority Research Publication PMCID:7494046
Sung AD, Jauhari S, Siamakpour-Reihani S, Rao AV, Staats J, Chan C, Meyer E, Gadi VK, Nixon AB, Lyu J, Xie J, Bohannon L, Li Z, Hourigan CS, Dillon LW, Wong HY, Shelby R, Diehl L, de Castro C, LeBlanc T, Brander D, Erba H, Galal A, Stefanovic A, Chao N, Rizzieri DA. Microtransplantation in older patients with AML: A pilot study of safety, efficacy and immunologic effects. Am J Hematol. 2020 Jun;95(6):662-671. PMCID:7433709
Hall RK, Cary MP Jr, Washington TR, Colón-Emeric CS. Quality of life in older adults receiving hemodialysis: a qualitative study. Qual Life Res. 2020 Mar;29(3):655-663. PMCID:7028790
Hall RK, Zhou H, Reynolds K, Harrison TN, Bowling CB. A Novel Approach to Developing a Discordance Index for Older Adults With Chronic Kidney Disease. J Gerontol A Biol Sci Med Sci. 2020 Feb 14;75(3):522-528. PMCID:7768728
Pavon JM, Sloane RJ, Pieper CF, Colón-Emeric CS, Cohen HJ, Gallagher D, Hall KS, Morey MC, McCarty M, Hastings SN. Accelerometer-Measured Hospital Physical Activity and Hospital-Acquired Disability in Older Adults. J Am Geriatr Soc. 2020 Feb;68(2):261-265. PMCID:7002200
Johnson KS, Payne R, Kuchibhatla MN. What are Hospice Providers in the Carolinas Doing to Reach African Americans in Their Service Area? J Palliat Med. 2016 Feb;19(2):183-189. Minority Research Publication PMCID:4753631
As an undergraduate nursing student at Duke, I vividly recall preparing for “the dreaded nursing home rotation:” an experience that was widely heralded as involving a LOT of hard work with little reward–the antithesis of the high-tech Duke we all embraced. Our preparation was a combination of “handoffs” from other nursing students regarding the idiosyncrasies of the residents in our care, and, pivotally, a guest lecture from Dr. Virginia Stone about age-related changes in the sensory system and how we could use that knowledge to improve our ability to communicate with these vulnerable older adults. Our predictions about the effort required by the rotation were well-founded; however, no one could have predicted the tremendous impact of that experience on my clinical and research career. For a young health professional-in-training, the nursing home held a treasure trove of lessons about complex chronic illness, family dynamics, and health care policy, and showcased the vital influence of nursing practice on outcomes of care for frail older adults. A student-led elective on successful aging, to which Dr. George Maddox contributed, and a community health rotation in the United Kingdom exposed me to important alternative models of care for frail elders that opened up the possibility of a career in geriatrics where I could make a difference.
After holding a series of clinical positions in both residential long-term care and geriatric community mental health, I joined the faculty of the fledgling Program on Aging at University of North Carolina at Chapel Hill (UNC-CH). There I learned the power of interdisciplinary team collaboration with medicine, social work, and rehabilitation professionals, who worked together to infuse geriatrics content into health professions curricula, provide clinical consultations in primary care, and engage with community partners to provide alternatives to nursing home care – work that I pursue to this day as co-leader of Duke’s newly funded Geriatric Workforce Enhancement Project (GWEP). I launched my research career with Drs. Virginia Neelon and Mary Champagne, as we led the first NIH-funded study at UNC-CH School of Nursing, focused on describing the natural history of acute confusion (delirium) in hospitalized elders. The NEECHAM scale, one of the first clinical measures of delirium was developed during this study, along with additional important insights such as the vulnerability of delirious patients to under-nutrition while hospitalized. Under the mentorship of Dr. Carol Clarke Hogue, I completed my PhD in nursing examining the combined effects of cognitive and physical impairment on disability among nursing homes residents with dementia. During this time, I returned to the “Duke orbit” by accepting a position with Dr. Stephanie Studenski, as a Clinical Nurse Specialist on an inpatient rehabilitation service at the Durham Veterans Affairs (VA) Medical Center, later transitioning to a position within the Durham VA’s Geriatric Research, Education and Clinical Center (GRECC). Today I continue my work at the Durham GRECC as a core investigator. I also serve as a tenured Associate Professor at the Duke University School of Nursing, and Director of the Duke Geriatric Nursing Center of Excellence, a member of the John A. Hartford national CGNE network, a focal point for integrating scholarship in research, education, and clinical practice in nursing care of older adults at Duke. One of the signature accomplishments of the Duke CGNE has been the development of the Duke NICHE (Nurses Improving Care of Health System Elders) programs, in partnership with colleagues in the Duke University Health System.
Two overarching aims drive my current research program: (1) How best to design, implement, and evaluate care approaches to improve the quality of life of older adults who have major neurocognitive disorders, and (2) How best to accelerate the process of implementing scientific discoveries in residential long-term care to improve resident outcomes. To address those aims, I am engaged in a variety of interprofessional research and education teams. Three ongoing studies illustrate how my program of research is unfolding. One study I currently lead focuses on establishing the feasibility of preparing master trainers to teach direct care staff Adaptive Dementia Care skills in governmentally-run nursing homes in the US and in China. Funded by the School of Nursing’s NIH-funded ADAPT Center, this study examines the amount of time required to teach registered nurses how to observe behavior sequences and adapt their care approach based on patient behavioral responses to specific approach and cueing techniques during basic care. Ultimately, the goal is to develop a scalable approach to teaching caregivers essential person-centered dementia care skills, taking into account cultural differences in the dementia care experience. Key collaborators on this study include Cheng Yun, Chief Nursing Officer at Huadong Hospital, one of the top geriatric hospitals in China, and Dr. Bei Wu, Director of International Research at the Duke School of Nursing. This project is helping to lay the foundation for ongoing collaborations between the School of Nursing and other key academic partners, including Duke Kunshan University (DKU) in China.
A second ongoing study, funded by the VA’s Health Services Research and Development (HSR&D) Quality Improvement Research Initiative (QUERI), for which I serve as site-principal investigator, involves a mixed-method, multi-center study, to examine the processes required to implement a home safety toolkit (HST) for Veterans who have dementia. Disciplines involved include advanced practice geriatric nursing, neurology, occupational therapy, and systems engineering. In a prior randomized trial, the HST was effective in improving caregiver self-efficacy and reducing caregiver burden. We are now examining clinical processes to promote rapid dissemination of this toolkit among primary care providers within two regions in the Veterans Health Administration (VHA). The ultimate goal of this work is to understand processes that support rapid adoption of evidence-based dementia care practices within large, integrated health care systems.
A third line of research, conducted in collaboration with Duke School of Nursing faculty colleagues Drs. Kirsten Corazzini and Lisa Day, concerns strengthening nursing practice in nursing homes at the clinical microsystem-level, to prevent avoidable hospitalizations. Building on work supported with funding from the Health Resources and Services Administration (HRSA) that supported a Dementia Grand Challenge to motivate improvements in care of people with dementia by linking continuing education learners, pre-professional learners, and faculty, we were approached by a nursing home corporate leader to assist with teaching nursing staff assessment skills to increase their capacity to prevent avoidable hospitalization among their residents with dementia. Dr. Day, who is an expert in situated learning, developed a continuing education series, using narrative pedagogy and unfolding cases to teach nursing home staff how to more effectively use approaches from INTERACT-II: a national program to prevent avoidable hospitalization. Early results are promising, and have led to a recent NIH submission by Drs. Corazzini and Vogelsmeier (University of Missouri) to study these approaches in a multi-state trial.
My colleagues and I welcome the opportunity to work with undergraduate students, graduate students, post-doctoral fellows, and faculty from a variety of professions and disciplines who share our passion for generating and implementing research-based approaches to address the many challenges facing older adults who live with major neurocognitive disorders and other complex chronic illnesses that lead to a need for long-term care.