Research

RESEARCH

The AGMP has assembled an international team of experts in Alzheimer's disease clinical and basic research as well as experts in the gut microbiome to work in close collaboration with centers of excellence in metabolomics, genetics, biochemistry, systems biology, and bioinformatics to accomplish our objectives.

DISEASE STRATIFICATION FOR PRECISION MEDICINE APPROACH TO AD

We systematically investigated group-specific metabolic alterations by conducting stratified association analyses of serum metabolites in individuals with measurements of AD biomarkers. Dissecting metabolic heterogeneity in AD pathogenesis can enable grading the biomedical relevance for specific pathways within specific subgroups, guiding the way to personalized medicine.

HOST-MICROBIOME CO-METABOLISM

Using the COBRA approach, Dr. Ines Thiele and her team have generated the first physiologically resolved whole-body, gender-specific metabolic models (WBMs) based on extensive organ-specific proteomic and metabolomic data, as well as through literature curation.

To learn more visit: https://www.thielelab.eu/research-projects

MOLECULAR ATLAS FOR AD

The AD atlas is a network-based data integration resource for investigating AD, its biomarkers, and associated endophenotypes in a multi-omics context. The database can be queried by entering one or more phenotypes, genes, proteins, or metabolites and provides an interactive interface to inspect generated networks, as well as enrichment tools for downstream analyses.

To learn more visit: https://adatlas.org/

NETWORK-BASED APPROACHES FOR ANALYZING METABOLITE ASSOCIATIONS

We use metabolomics as a global biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to AD biomarkers including cerebrospinal fluid pathology, brain imaging features, and cognitive performance.

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GLOBAL NATURAL PRODUCTS SOCIAL MOLECULAR NETWORKING

Global Natural Products Social Molecular Networking (GNPS) is a web-based mass spectrometry ecosystem that aims to be an open-access knowledge base for community-wide organization and sharing of raw, processed or identified tandem mass (MS/MS) spectrometry data. GNPS aids in identification and discovery throughout the entire life cycle of data; from initial data acquisition/analysis to post publication.

To learn more visit: https://dorresteinlab.ucsd.edu/gnps

QUANTITATIVE INSIGHTS INTO MICROBIAL ECOLOGY

Quantitative Insights Into Microbial Ecology (QIIME) is an open-source bioinformatics pipeline for performing microbiome analysis from raw DNA sequencing data. QIIME is designed to take users from raw sequencing data generated on the Illumina or other platforms through publication quality graphics and statistics.

To learn more visit: http://qiime.org/

U.S. POINTER

The U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (US POINTER) is a two-year clinical trial to evaluate whether lifestyle interventions that simultaneously target many risk factors protect cognitive function in older adults who are at increased risk for cognitive decline

MIND DIET TRIAL

Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) Trial to Prevent Alzheimer's is a three year research study that compares two weight loss diets and their effects on brain health and cognitive decline.

BEAT-AD CLINICAL TRIAL

Brain Energy for Amyloid Transformation in Alzheimer's Disease Study (BEAT-AD) compares the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment. The data collected will help determine whether diet interventions induce changes in cognition, cerebral blood flow, and levels of certain proteins and hormones.

MICROBIAL METABOLITE DATABASE

Through our partnership with Leiden University and the greater metabolomics community, we are working to establish a comprehensive database for microbial metabolites. Interconnected modules in the database will allow for dynamic browsing and search combinations.

MOLECULAR NETWORKING

Molecular networking is a strategy that first merges all identical spectra and then creates a map of MS/MS similarity from which chemical similarity can be inferred. Molecular networking allows the discovery of molecules that are not identical but are related to known
molecules.

GLOBAL FOOD OMICS

The Global Food Omics initiative was launched at UC San Diego in collaboration with the American Gut Project, to learn more about bacteria in foods and the small molecules they produce.

To learn more visit: Global Food Omics