Project 3: Mechanistic Studies on Role of Microbiome in Models for AD
Utilizes preclinical models to measure disease-specific outcomes across stages of Alzheimer’s Disease
- Establish and define gut-microbiome-brain connections in preclinical models of AD.
- Transplant human microbiomes from AD patients and controls into mice to characterize functional contributions to disease.
- Test if defined human microbes and specific metabolites modulate symptoms and pathology in AD mouse models