Cores

Cores

The Administrative Core will provide structure and oversight to enable the AGMP to achieve its goal to define the gut-brain-chemical axis of communication and the role for the gut microbiome in Alzheimer’s Disease pathogenesis. It ensures that all Projects and Cores are integrated, and function effectively and efficiently.

The core oversees the integration of data developed by collaborators, coordinates the interactions with the National Centralized Repository for Alzheimer’s Disease and Related Dementias (NCRAD) -serving as the repository of collected biospecimens for the project- which are made available to collaborators and the greater research community.

This Core is co-led by Rima Kaddurah-Daouk (Duke University), Rob Knight (UC San Diego), and Sarkis Mazmanian (CalTech) who bring considerable leadership experience and complementary scientific expertise to AGMP.

  • Dr. Kaddurah-Daouk serves as the contact PI, and brings experience having successfully led four large NIH-funded consortia and is a pioneer in the application of metabolomics in neuropsychiatric diseases, including defining a role for the gut microbiome in AD.
  • Dr. Knight runs the American Gut Project/The Microsetta Initiative and developed microbiome technologies widely used in the field.
  • Dr. Mazmanian discovered a role for the gut microbiome in the pathogenesis of neuropsychiatric diseases.

Main objectives:

  • Integration of data developed by collaborators through the creation of a relational database to manage all data-related activities
  • Creation of a repository of uniformly collected biospecimens at the Nationalized Centralized  Repository for Alzheimer’s and Related Dementias (NCRAD) which will be made available to collaborators and the greater research community.