Molecular Mechanisms of Vascular Etiology of Alzheimer’s Disease

The ADMC is also one of five consortia funded by the National Institute of Aging’s large initiative:

M²OVE-AD: Molecular Mechanisms of the Vascular Etiology of Alzheimer’s Disease

Seeking a better understanding of vascular contributions to Alzheimer’s disease, the National Institutes of Health launched the Molecular Mechanisms of the Vascular Etiology of Alzheimer’s Disease (M²OVE-AD) Consortium, a team-science venture to build a nuanced model of Alzheimer’s disease that more accurately reflects its many causes and pathways. Scientists have long been interested in how the vascular system—the body’s network of large and small blood vessels—may be involved in the onset and progression of Alzheimer’s disease and related dementias. Scientists from diverse fields using the latest methodologies will work collaboratively towards shared goals: to dissect the complex molecular mechanisms by which vascular risk factors influence Alzheimer’s disease and identify new targets for treatment and prevention.

Developed by the National Institute on Aging (NIA) and the National Institute of Neurological Disorders and Stroke (NINDS), both part of NIH, the five-year, $30-million program brings together

over a dozen research teams working on five complementary projects. Harnessing the power of new molecular technologies and big data analytics, the teams will make biological datasets available to the wider research community.

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