The Acharya Lab is a structural biology research group at Duke University, dedicated to advancing molecular-level understanding of pathogen-host interactions, virus entry and host defenses against viruses and other pathogens. As part of the Duke Human Vaccine Institute (DHVI) and the Duke Center for HIV Structural Biology (DCHSB), the Acharya Lab works in close collaboration with virologists, immunologists, and computational biologists to translate fundamental discoveries into impactful medical solutions.
Our MissionÂ
Our goal is to understand the mechanisms of virus entry into host and to leverage this understanding for the development of effective countermeasures. We use atomic level structures to uncover the detailed molecular architecture of viral surface glycoproteins and their interactions with the host immune system. We combine structural understanding with biophysical and biochemical studies, and utilize protein engineering tools to design and modify proteins. Through this approach, we strive to translate fundamental structural insights into actionable strategies for rational development of medical countermeasures against current and emerging viral threats. An important part of our mission is to provide an invigorating and collaborative environment for research, training and career growth.
Significance of our research
Surface glycoproteins play a critical role in mediating viral entry into host cells and are key targets of the immune response. Hence, understanding the structure of viral glycoproteins is essential for developing effective medical countermeasures. High-resolution structural analysis provides essential insights into how viruses engage host receptors and evade immune defenses. This knowledge forms the foundation for the rational design of vaccines and therapeutics aimed at protecting from current and future threats.
The Acharya Lab is featured in a Webedge Science video highlighting the contributions of Duke Center for HIV Structural Biology (DCHSB) to HIV envelope research. Watch the video to learn more about our work advancing structural insights into HIV vaccine design!
