We are interested in embryonic brain development. We study neurogenesis of the developing cerebral cortex, whereby neurons (blue, right) are produced from neural progenitors (red). Defective neurogenesis impacts neuron production, and can result in neurodevelopmental disorders affecting brain size and structure. Amongst the research questions we are asking in the lab include:
- What is the genetic basis for human neocortical traits such as larger brain size?
- What genes control embryonic brain development and underlie neurodevelopmental disease?
- How do RNA binding proteins regulate cell fate decisions?
We tackle these complex questions using multidisciplinary approaches including live imaging of brain slices and neural progenitors, genetics, and functional genomics.
Recent News from our lab:
- **Check out our recent paper on a requirement for Rbm8a in regulating brain size, featured on the cover of The Journal of Neuroscience and in a news and views article!
- **Learn about our recent study on evolutionary-important enhancers published in Current Biology, with an interview on NPR!
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