We aim to understand how the embryonic brain develops. We study neurogenesis of the developing cerebral cortex, the process in which neurons are produced from neural progenitors. Defective neurogenesis impacts neuron production, and can result in neurodevelopmental disorders affecting brain size and structure. We have two major research interests in the lab:
- Genetic basis of brain development and evolution
- Progenitor cell fate specification and RNA regulation
We tackle these complex questions using multidisciplinary approaches including live imaging of brain slices and neural progenitors, mouse genetics, and functional genomics.
Recent News from our lab:
- Read our most recent paper in Neuron! Prolonged mitosis of neural progenitors alters cell fate in the developing brain.
- Learn about RNA binding proteins in neural progenitors and cortical development in our recent review in WIREs RNA.
- Learn about our work on evolutionary-important enhancers published in Current Biology, with an interview with Debby on NPR!
Follow us on Twitter @TheSilverLab