We study development of the embryonic cerebral cortex, the brain structure which controls higher cognitive function. In the developing cerebral cortex, neurons (blue, right) are produced from neural progenitors (red) during a process called neurogenesis. Defective neurogenesis impacts neuron production, which can result in neurodevelopmental disorders affecting brain size and structure.
We are interested in the following research questions:
- What is the genetic basis for human neocortical traits such as larger brain size?
- What genes control embryonic brain development and underlie neurodevelopmental disease?
We tackle these complex questions using multidisciplinary approaches including live imaging of brain slices and neural progenitors, genetics, and functional genomics.
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