We aim to understand how the embryonic brain develops. We study neurogenesis of the developing cerebral cortex, whereby neurons are produced from neural progenitor populations. Defective neurogenesis impacts neuron production, and can result in neurodevelopmental disorders affecting brain size and structure. Amongst the research questions we are asking in the lab are the following:
- What is the genetic basis for evolution and development of the human cerebral cortex?
- How is RNA regulation coupled to cell fate decisions of neural progenitors and the etiology of neurodevelopmental disease?
We tackle these complex questions using multidisciplinary approaches including live imaging of brain slices and neural progenitors, mouse genetics, and functional genomics.
Recent News from our lab:
- Silver lab’s recent publication in Current Biology is the subject of a feature story in Science Magazine.
- Learn about roles for RNA binding proteins in neural progenitors and cortical development in our recent review out in WIREs RNA!
- Check out our recent paper on a requirement for the RNA binding protein Rbm8a in brain size, featured on the cover of The Journal of Neuroscience and in a news and views article!
- Learn about our recent study on evolutionary-important enhancers published in Current Biology, with an interview with Debby on NPR!
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