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Duke University, Durham, NC, USA (GPA 3.9/4) (2006-9/2012*)
Ph.D. candidate, Molecular Genetics and Microbiology
Novosibirsk State University, Novosibirsk, Russia (GPA 3.9/4) (2001-2006)
Honors specialist diploma (5 year degree), Molecular Biology
Graduate Research Assistant, Mentor: Matthias Gromeier, Ph.D. (2007 – present)
Duke University Medical Center, Durham, NC USA
Mechanism of inhibition of host translation during HSV-1 lytic infection
- Collaborating with other members of laboratory discovered HSV-1 proteins that interact with cellular translation initiation machinery.
- Analyzed subcellular distribution of host and viral proteins by immunofluorescence.
Control of eukaryotic translation initiation by MAPK signal transduction
- Utilized co-immunoprecipitation assays to investigate interaction of Mnk1 kinase with critical translation initiation factor eIF4G under a variety of physiological conditions.
- Created a panel of mutants to decipher the effect of phosphostatus and activity of Mnk1 on its binding to eIF4G.
Cdk1/cyclin B1 effect on protein synthesis in mitosis
- Employed phosphoproteomics to analyze the phosphorylation status of eIF4G in mitosis vs interphase.
- Investigated in vivo and in vitro phosphorylation of eIF4G by Cdk1/cyclin B1 kinase.
- Created inducible knock-out/knock-in cell lines to study the function of phosphomutant eIF4G.
- Currently investigating the effect of phosphorylation of eIF4G on mitotic translation utilizing metabolic labeling, luciferase reporters and polysomal profiling/qPCR.
Undergraduate Research Assistant, Mentor: Nina Tikunova, Ph.D. (2004 –2006)
Novosibirsk State University, Novosibirsk, Russia
- Applied phage display to select human recombinant antibodies to IL-18
- Dobrikov M, Dobrikova E, Shveygert M, Gromeier M. Phosphorylation of eIF4G1 by PKCα Regulates Interaction with Mnk1. Mol. Cell. Biol. 2010 Nov;30(21):5160-7
- Shveygert M, Bradrick S, Kaiser C, Gromeier M. Regulation of eIF4E phosphorylation by MAPK occurs through modulation of Mnk1-eIF4G interaction Mol. Cell. Biol. 2010 Nov;30(21):5160-7
- Goetz C, Dobrikova E, Shveygert M, Dobrikov M, Gromeier M. Oncolytic poliovirus against malignant glioma. Future Virology, Sep 2011, Vol. 6, No. 9, Pages 1045-1058.
- Dobrikova E*, Shveygert M*, Walters R, Gromeier M. Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution. JVirol. 2010 Jan;84(1):270-9. *These authors contributed equally to this work
- Vikhrova MA, Shveygert MV, Khrapov EA, Filipenko ML, Gileva IP, Morozova VV, Tikunova NV.Selection of naturally occurring autoantibodies to interleukin-18 from phage display library. Hum Antibodies. 2010;19(2-3):71-8.
- Kaiser C, Dobrikova EY, Bradrick SS, Shveygert M, Herbert JT, Gromeier M. Activation of cap-independent translation by variant eukaryotic initiation factor 4G in vivo. RNA 2008 Oct;14(10):2170-82.
- Bradrick SS, Dobrikova EY, Kaiser C, Shveygert M, Gromeier M. Poly(A)-binding protein is differentially required for translation mediated by viral internal ribosomal entry site. RNA 2007 Sep;13(9):1582-93.
Awards and Fellowships
- Selected poster prize; Symposium on RNA biology, Durham, NC USA (2009)
- Best student oral presentation award; MGM retreat, Durham, NC USA (2009)
- Conference travel fellowship from Duke University Graduate School (2008, 2012)
- Diploma for the best talk at the XLIV International Scientific Conference Novosibirsk, Russia (2006)
- V. Potanin Federal Scholarship for Academic Excellence (2004-2006)
Meetings and Conferences
- Protein Translation and Cancer; Coronado, CA USA (2010)
- Symposium on RNA Biology; Durham, NC USA (2009)
- Translational Control Meeting, CSHL, NY USA (2008)
- XLIV International Scientific Student Conference; Novosibirsk, Russia (2006)
Teaching and Mentoring
- Teaching assistant for General Microbiology course at Duke University (Fall 2010)
Prepared and taught 2 labs/week for 16 students, graded tests, exams and final projects
- Participated in ‘Teaching biology’ certificate program at Duke University (2010-2011)
- Mentored medical student one-year research project at DUMC (2010-2011)
Service and Leadership
Volunteered at Duke International House (2007-2010)
- Prepared and facilitated 2-day orientation involving over 200 incoming international students
- Advised a group of 40 international student on accommodating to Duke campus and U.S. culture
- Assisted Cross-Cultural Counseling workshops
- English (fluent)
- Russian (native)
- Spanish (advanced)
- German (basic)