Currently, we cannot experimentally see biomolecules performing their cellular functions – such as DNA replication and protein catalysis – at atomic resolution. Our group is developing methods that combine powerful Nuclear Magnetic Resonance (NMR) experiments with computational approaches – that make it possible to visualize the dynamics of biomolecules at atomic resolution. These atomic “movies” are allowing us to understand some of the most curious aspects of biomolecule behavior, such as how they change structure in a specific manner, make new discoveries that redefine the iconic DNA double helix, and also enabling biotechnological applications, such as RNA-targeted drug discovery.
03.2016 Bei Liu and Atul Rangadurai join the lab as graduate students from Duke Biochemistry.
01.2016 Honglue Shi joins the lab as a graduate student from Duke Chemistry.
11.2015 Congratulations to Anisha and Yi on acceptance of their manuscript entitled “Rapid Exchange Between Free and Bound States in RNA-Dendrimer Polyplexes: Implications on the Mechanism of Delivery and Release” in Biomacromolecules.
10.2015 Congratulations to former member Tony Mustone on acceptance of paper entitled “Secondary structure encodes a cooperative tertiary folding funnel in the Azoarcus ribozyme” in NAR.
10.2015 Congratulation to Yi on acceptance of his paper entitled “Structural and Dynamic Basis for Low Affinity-High Selectivity Binding of L-glutamine by the Gln-riboswitch” in Cell Reports.
09.2015 Congrats to Loic, Jeet, Dan, and Yi on the acceptance of their paper entitled “Engineering a Therapeutic Lectin: Uncoupling Mitogenicity from Antiviral Activity” in Cell.
09.2015 Congratulations to Dr. Yu Chen who successfully defended her thesis at U-M. Dr. Chen was a joint graduate student between the Al-Hashimi Lab and the Fierke lab at U-M.
09.2015 Dr. Allison Stelling joins the lab as a postdoctoral fellow.